一氟甲基多巴对单胺合成抑制作用的进一步研究
Further studies on the inhibition of monoamine synthesis by monofluoromethyldopa.
作者信息
Bey P, Jung M J, Koch-Weser J, Palfreyman M G, Sjoerdsma A, Wagner J, Zraïka M
出版信息
Br J Pharmacol. 1980 Dec;70(4):571-6. doi: 10.1111/j.1476-5381.1980.tb09776.x.
Abstract
1 alpha-Monofluoromethyldopa (MFMD, RMI 71963), a potent and selective enzyme-activated irreversible inhibitor of aromatic L-amino acid decarboxylase produces a substantial and long-lasting decrease in the catecholamine content of mouse brain, heart and kidney. 2 Single doses of MFMD reduce the 5-hydroxytryptamine concentration of mouse brain without altering the tryptophan concentration. 3 In animals treated with MFMD, peripheral but not brain noradrenaline is restored within 1 h to control levels by an intraperitoneal injection of dopamine.
摘要
- α-单氟甲基多巴（MFMD，RMI 71963），一种强效且选择性的酶激活不可逆芳香族L-氨基酸脱羧酶抑制剂，可使小鼠脑、心脏和肾脏中的儿茶酚胺含量大幅且持久地降低。2. 单剂量的MFMD可降低小鼠脑中5-羟色胺的浓度，而不改变色氨酸浓度。3. 在接受MFMD治疗的动物中，腹腔注射多巴胺可在1小时内使外周而非脑内的去甲肾上腺素恢复至对照水平。
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引用本文的文献
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本文引用的文献
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ELUCIDATION OF THE RATE-LIMITING STEP IN NOREPINEPHRINE BIOSYNTHESIS IN THE PERFUSED GUINEA-PIG HEART.灌注豚鼠心脏中去甲肾上腺素生物合成限速步骤的阐明
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Selective inhibitors of biosynthesis of aminergic neurotransmitters.胺能神经递质生物合成的选择性抑制剂。
Nature. 1978 Aug 31;274(5674):906-8. doi: 10.1038/274906a0.
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J Chromatogr. 1979 Sep 11;164(1):41-54. doi: 10.1016/s0378-4347(00)81570-4.
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alpha-difluoromethyl DOPA, a new enzyme-activated irreversible inhibitor of aromatic L-amino acid decarboxylase.
J Neurochem. 1978 Oct;31(4):927-32. doi: 10.1111/j.1471-4159.1978.tb00129.x.
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