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一氟甲基多巴对单胺合成抑制作用的进一步研究

Further studies on the inhibition of monoamine synthesis by monofluoromethyldopa.

作者信息

Bey P, Jung M J, Koch-Weser J, Palfreyman M G, Sjoerdsma A, Wagner J, Zraïka M

出版信息

Br J Pharmacol. 1980 Dec;70(4):571-6. doi: 10.1111/j.1476-5381.1980.tb09776.x.

DOI:10.1111/j.1476-5381.1980.tb09776.x
PMID:7470730
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2044376/
Abstract

1 alpha-Monofluoromethyldopa (MFMD, RMI 71963), a potent and selective enzyme-activated irreversible inhibitor of aromatic L-amino acid decarboxylase produces a substantial and long-lasting decrease in the catecholamine content of mouse brain, heart and kidney. 2 Single doses of MFMD reduce the 5-hydroxytryptamine concentration of mouse brain without altering the tryptophan concentration. 3 In animals treated with MFMD, peripheral but not brain noradrenaline is restored within 1 h to control levels by an intraperitoneal injection of dopamine.

摘要
  1. α-单氟甲基多巴（MFMD，RMI 71963），一种强效且选择性的酶激活不可逆芳香族L-氨基酸脱羧酶抑制剂，可使小鼠脑、心脏和肾脏中的儿茶酚胺含量大幅且持久地降低。2. 单剂量的MFMD可降低小鼠脑中5-羟色胺的浓度，而不改变色氨酸浓度。3. 在接受MFMD治疗的动物中，腹腔注射多巴胺可在1小时内使外周而非脑内的去甲肾上腺素恢复至对照水平。

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1
Further studies on the inhibition of monoamine synthesis by monofluoromethyldopa.一氟甲基多巴对单胺合成抑制作用的进一步研究
Br J Pharmacol. 1980 Dec;70(4):571-6. doi: 10.1111/j.1476-5381.1980.tb09776.x.
2
Depression of sympathetic nervous function by DL-alpha-monofluoromethyldopa, an enzyme-activated, irreversible inhibitor of L-aromatic amino acid decarboxylase.
J Cardiovasc Pharmacol. 1980;2(3):229-45. doi: 10.1097/00005344-198005000-00002.
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A method for measuring monoamine turnover in animals using an irreversible inhibitor of aromatic L-amino acid decarboxylase, DL-alpha-mono fluoromethyldopa.一种使用芳香族L-氨基酸脱羧酶不可逆抑制剂DL-α-单氟甲基多巴来测量动物体内单胺周转率的方法。
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Use of D,L-alpha-monofluoromethyldopa to distinguish subcellular pools of aromatic amino acid decarboxylase in mouse brain.使用D，L-α-单氟甲基多巴区分小鼠脑中芳香族氨基酸脱羧酶的亚细胞池。
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Effect of monofluoromethyldopa (MFMD) on trace amine levels.单氟甲基多巴（MFMD）对痕量胺水平的影响。
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引用本文的文献

1
Alpha-Monofluoromethyldopa (MFMD) in combination with L-DOPA Effects on tissue catecholamines and blood pressure in rats.
Naunyn Schmiedebergs Arch Pharmacol. 1982 Oct;321(1):28-31. doi: 10.1007/BF00586344.
2
Cerebral decarboxylation of meta- and para-tyrosine.间位和对位酪氨酸的脑内脱羧作用。
Experientia. 1983 Feb 15;39(2):130-4. doi: 10.1007/BF01958860.

本文引用的文献

1
ELUCIDATION OF THE RATE-LIMITING STEP IN NOREPINEPHRINE BIOSYNTHESIS IN THE PERFUSED GUINEA-PIG HEART.灌注豚鼠心脏中去甲肾上腺素生物合成限速步骤的阐明
J Pharmacol Exp Ther. 1965 Apr;148:1-8.
2
Decarboxylase inhibitors.脱羧酶抑制剂
Pharmacol Ther B. 1975;1(3):407-21. doi: 10.1016/0306-039x(75)90047-1.
3
Selective inhibitors of biosynthesis of aminergic neurotransmitters.胺能神经递质生物合成的选择性抑制剂。
Nature. 1978 Aug 31;274(5674):906-8. doi: 10.1038/274906a0.
4
Determination of dopa, dopamine, dopac, epinephrine, norepinephrine, alpha-monofluoromethyldopa and alpha-difluoromethyldopa in various tissues of mice and rats using reversed-phase ion-pair liquid chromatography with electrochemical detection.使用反相离子对液相色谱-电化学检测法测定小鼠和大鼠各种组织中的多巴、多巴胺、二羟基苯乙酸、肾上腺素、去甲肾上腺素、α-单氟甲基多巴和α-二氟甲基多巴。
J Chromatogr. 1979 Sep 11;164(1):41-54. doi: 10.1016/s0378-4347(00)81570-4.
5
Inhibition of peripheral sympathetic function by alpha-monofluoromethyldopa, an irreversible inhibitor of aromatic amino acid decarboxylase [proceedings].α-单氟甲基多巴（一种芳香族氨基酸脱羧酶不可逆抑制剂）对周围交感神经功能的抑制作用[会议论文集]
Br J Pharmacol. 1979 Nov;67(3):461P.
6
Monamine-depleting properties of a new and very potent enzyme-activated irreversible inhibitor of aromatic aminoacid decarboxylase: alpha-monofluoromethyldopa [proceedings].一种新型且强效的芳香族氨基酸脱羧酶酶激活不可逆抑制剂——α-单氟甲基多巴的单胺耗竭特性[会议论文集]
Br J Pharmacol. 1979 Nov;67(3):460P.
7
Inhibition of monoamine synthesis by irreversible blockade of aromatic aminoacid decarboxylase with alpha-monofluoromethyldopa.
Life Sci. 1979 Mar 12;24(11):1037-42. doi: 10.1016/0024-3205(79)90324-2.
8
alpha-difluoromethyl DOPA, a new enzyme-activated irreversible inhibitor of aromatic L-amino acid decarboxylase.
J Neurochem. 1978 Oct;31(4):927-32. doi: 10.1111/j.1471-4159.1978.tb00129.x.