Johnson A K, Buggy J, Fink G D, Brody M J
Brain Res. 1981 Feb 2;205(2):255-64. doi: 10.1016/0006-8993(81)90337-1.
Various lines of research have implicated the central nervous system in the development of renal hypertension. The ablation of a periventricular region surrounding the anteroventral third ventricle (AV3V) has been shown to block the development of renal hypertension. Because of hemodynamic effects produced by AV3V electrical stimulation can be abolished by a midline lesion of the ventromedial hypothalamic--median eminence region (VMH-ME), the effect of VMH-ME ablation on the development of renal hypertension was studied. Following recovery from surgery that destroyed the VMH-ME region the lesioned rats and controls were subjected to unilateral nephrectomy and figure-of-eight wrapping of the remaining kidney. Control animals developed renal hypertension but those with VMH-ME lesions did not. When the pressor response produced by intracerebroventricular injections of angiotensin II was studied, it was found that rats with VMH-ME lesions, as compared to neurologically intact animals, showed significantly attenuated responses. The data suggest that a neural system related to cardiovascular control descends through the VMH-ME region and that the integrity of this pathway is necessary for the development of renal hypertension.
多项研究表明中枢神经系统与肾性高血压的发生有关。已证实，损毁围绕第三脑室前腹侧（AV3V）的脑室周区域可阻止肾性高血压的发生。由于AV3V电刺激产生的血流动力学效应可被腹内侧下丘脑 - 正中隆起区域（VMH - ME）的中线损伤消除，因此研究了VMH - ME损毁对肾性高血压发生的影响。在损毁VMH - ME区域的手术恢复后，对损毁大鼠和对照组进行单侧肾切除及对剩余肾脏进行“8”字形包裹。对照动物出现了肾性高血压，而VMH - ME损伤的动物则未出现。当研究脑室内注射血管紧张素II产生的升压反应时，发现与神经功能正常的动物相比，VMH - ME损伤的大鼠反应明显减弱。数据表明，一条与心血管控制相关的神经系统通过VMH - ME区域下行，并且该通路的完整性对于肾性高血压的发生是必要的。
