Arlett C F, Harcourt S A
Cancer Res. 1980 Mar;40(3):926-32.
gamma-Ray sensitivity for cell killing was assayed in 54 human cell strains, including some derived from individuals suffering from certain heritable diseases. The overall range of Do values in this study was 38 to 180 rads, indicating a considerable range of variability in humans. The normal sensitivity was described by a range of Do values of 97 to 180 rads. All ten ataxia telangiectasia cell strains tested proved radiosensitive and gave a mean Do value of 57 +/- 15 (S.E.) rads, and these represent the most radiosensitive human skin fibroblasts currently available. Representative cell strains from familial retinoblastoma, Fanconi's anemia, and Hutchinson-Gilford progeria occupied positions of intermediate sensitivity, as did one of two ataxia telangiectasia heterozygotes. Six xeroderma pigmentosum cell strains together with two Cockayne's syndrome cell strains (all known to be sensitive to ultraviolet light) fell into the normal range, indicating an absence of cross-sensitivity between ultraviolet light and gamma-irradiation.
在54种人类细胞株中检测了细胞杀伤的γ射线敏感性，其中包括一些来自患有某些遗传性疾病个体的细胞株。本研究中Do值的总体范围为38至180拉德，表明人类存在相当大的变异性。正常敏感性由97至180拉德的Do值范围描述。所测试的所有10种共济失调毛细血管扩张症细胞株均被证明对辐射敏感，平均Do值为57±15（标准误）拉德，这些代表了目前可得的最敏感的人类皮肤成纤维细胞。来自家族性视网膜母细胞瘤、范科尼贫血和哈钦森 - 吉尔福德早衰症的代表性细胞株以及两个共济失调毛细血管扩张症杂合子之一处于中等敏感性位置。六种着色性干皮病细胞株与两种科凯恩综合征细胞株（均已知对紫外线敏感）处于正常范围内，表明紫外线和γ射线照射之间不存在交叉敏感性。
