Gelb A M, Richman B L, Anand O P
Am J Drug Alcohol Abuse. 1978;5(2):191-8. doi: 10.3109/00952997809027997.
Evidence exists that alcohol abuse frequently coexists with narcotic addiction and methadone maintenance treatment, and it is the major factor in the development of cirrhosis and liver failure. This study of patients hospitalized for alcohol detoxification compares the quantity of alcohol consumed by alcohol abusers, addicted to narcotics or in a methadone maintenance treatment program, to that consumed by patients not involved with narcotic addiction. Mean daily alcohol consumption was not significantly different in either group using narcotics, including methadone, or in the subgroup of methadone maintenance patients, from the amount consumed by nonnarcotic abusers. Determination of temporal sequence in the use of these substances revealed that in 68% regular alcohol abuse preceded narcotic use. Alcohol abuse reportedly began after entering a methadone maintenance treatment program in 29% of our patients. Alcohol abusers who were in a methadone maintenance treatment program were significantly younger than those who did not use narcotics, including methadone. Time interval according to the patients' estimates, from onset of regular alcohol consumption to heavy drinking, was not significantly different in the two groups.
有证据表明,酒精滥用常常与麻醉品成瘾及美沙酮维持治疗同时存在,且它是肝硬化和肝衰竭发展的主要因素。这项针对因酒精戒断而住院的患者的研究,比较了滥用酒精且对麻醉品成瘾或处于美沙酮维持治疗项目中的患者的酒精消费量,与未涉及麻醉品成瘾的患者的酒精消费量。使用麻醉品(包括美沙酮)的任何一组患者,以及美沙酮维持治疗患者亚组的日均酒精消费量,与非麻醉品滥用者的消费量相比,均无显著差异。对这些物质使用时间顺序的确定显示,68%的患者是先有规律地滥用酒精,之后才使用麻醉品。据报告,29%的患者在进入美沙酮维持治疗项目后才开始酒精滥用。处于美沙酮维持治疗项目中的酒精滥用者明显比未使用麻醉品(包括美沙酮)的人年轻。根据患者估计,从开始有规律地饮酒到酗酒的时间间隔,两组之间无显著差异。