Fairshter R D, Wilson A F
Chest. 1980 Jul;78(1):44-50. doi: 10.1378/chest.78.1.44.
Pulmonary function tests were performed before and after inhalation of 1.3 mg of metaproterenol sulfate or 150 microgram of isoproterenol hydrochloride by 40 asthmatic and 40 normal subjects. PHysiologic measurements included spirometric testing, plethysmographic studies, and maximal expiratory flow-volume curves obtained after inhalation of air and a mixture of 80 percent helium and 20 percent oxygen. In the normal subjects, pulmonary function improved significantly after inhalation of both metaproterenol and isoproterenol. There was no significant difference in responsiveness to either bronchodilator drug. In the asthmatic subjects, pulmonary function also improved significantly after both bronchodilator agents. The sites of predominant bronchodilatation were similar in the asthmatic subjects after both metaproterenol and isoproterenol; however, bronchodilatation was better overall (P less than 0.005) and for most individual tests with metaproterenol. The greater efficacy of metaproterenol in asthmatic subjects but not in normal subjects can be explained by (1) different doses of the bronchodilator drug and (2) differing bronchodilator dose-response relationships in asthmatic and normal subjects.
对40名哮喘患者和40名正常受试者吸入1.3毫克硫酸间羟异丙肾上腺素或150微克盐酸异丙肾上腺素前后进行了肺功能测试。生理测量包括肺量计测试、体积描记法研究，以及吸入空气和80%氦气与20%氧气的混合气体后获得的最大呼气流量-容积曲线。在正常受试者中，吸入间羟异丙肾上腺素和异丙肾上腺素后肺功能均显著改善。对两种支气管扩张剂药物的反应性无显著差异。在哮喘患者中，两种支气管扩张剂使用后肺功能也显著改善。间羟异丙肾上腺素和异丙肾上腺素使用后，哮喘患者主要支气管扩张的部位相似；然而，总体而言，间羟异丙肾上腺素的支气管扩张效果更好（P<0.005），且在大多数个体测试中也是如此。间羟异丙肾上腺素在哮喘患者而非正常受试者中疗效更佳，原因可能为：（1）支气管扩张剂药物剂量不同；（2）哮喘患者和正常受试者的支气管扩张剂剂量-反应关系不同。
