Orfanos C E, Landes E, Bloch P H
Ann Dermatol Venereol. 1978 Oct;105(10):807-11.
17 patients with pustular psoriasis, i. e. 9 generalized and 8 localized types, were treated orally with the new aromatic retinoid RO 10-9359. The given dose was 0.5-1.0 mg/kg body weight per day. After 4-8 weeks the result was very good or good in 13 cases. Side effects were moderate; only in one female patient the oral treatment was interrupted because of drug-induced alopecia. Histologic examinations revealed spongiform pustules before treatment and typical features of psoriasis vulgaris after 2 weeks; after 4 weeks most tissue changes had returned to normal. An unusual fine granular mucoid material was seen under the electron microscope in the intercellular spaces of the epidermis, being most likely produced in the keratinocytes.
