Bialasiewicz A A, Kopp U, Mahlstedt J, Ogilvie A, Graupner G
Graefes Arch Clin Exp Ophthalmol. 1983;220(6):268-72. doi: 10.1007/BF00231354.
The effects of retinoid Ro 10-9359 no normal albino rabbit eyes and antigen-induced intra-ocular inflammations were investigated. The distribution pattern of intravenously applied 3H--Ro 10-9359 correlated well with the sites of pharmacological action. Whereas immunologically naive rabbits showed a uveal uptake of 0.164 ng/g wet wt. tissue when 100 micrograms of Ro 10-9359 was administered intravenously, accumulation may amount up to 17.46 ng/g in secondary ocular immune responses. Ro 10-9359 accumulated markedly during secondary stimulation in the uvea, preauricular lymph nodes and the spleen. The chemotactic peptide NForm-Leu-Leu-Phe used to incite a hypopyon attracted Ro 10-9359 into the anterior chamber in vivo. This study indicates that the aromatic retinoid Ro 10-9359 is able to alter certain immune responses and may be involved in intercellular communication during secondary immune responses in the albino rabbit eye.
研究了类视黄醇Ro 10-9359对正常白化兔眼及抗原诱导的眼内炎症的影响。静脉注射3H-Ro 10-9359的分布模式与药理作用部位密切相关。当静脉注射100微克Ro 10-9359时，免疫未激活的兔子眼葡萄膜摄取量为0.164纳克/克湿重组织，而在二次眼部免疫反应中，蓄积量可达17.46纳克/克。在二次刺激过程中，Ro 10-9359在葡萄膜、耳前淋巴结和脾脏中明显蓄积。用于诱发前房积脓的趋化肽N-甲酰-亮氨酰-亮氨酰-苯丙氨酸在体内可将Ro 10-9359吸引至前房。本研究表明，芳香族类视黄醇Ro 10-9359能够改变某些免疫反应，可能参与白化兔眼二次免疫反应期间的细胞间通讯。
