Uchino B N, Cacioppo J T, Malarkey W, Glaser R
Department of Psychology/Health Psychology Program, University of Utah, Salt Lake City 84112, USA.
J Pers Soc Psychol. 1995 Oct;69(4):736-43. doi: 10.1037//0022-3514.69.4.736.
Potential mechanisms coordinating individual differences in cardiovascular reactivity and endocrine and immune responses to acute psychological stress were examined. Twenty-three young, healthy women performed a mental arithmetic challenge while measures of cardiovascular, endocrine, and immune function were assessed. Results revealed that the acute stressor was associated with changes in the cardiovascular, endocrine, and immune systems. More important analyses revealed that individual differences in cardiovascular reactivity predicted stress-induced cortisol changes. Furthermore, cardiac sympathetic control, as indexed by preejection period, was specifically related to changes in natural killer cell activity. These results suggest that distinct physiological pathways are activated in response to acute psychological stress.
研究了协调心血管反应性以及对急性心理应激的内分泌和免疫反应的个体差异的潜在机制。23名年轻健康女性在进行心算挑战的同时，对心血管、内分泌和免疫功能进行了评估。结果显示，急性应激源与心血管、内分泌和免疫系统的变化有关。更重要的分析表明，心血管反应性的个体差异可预测应激诱导的皮质醇变化。此外，以射血前期为指标的心脏交感神经控制与自然杀伤细胞活性的变化有特定关联。这些结果表明，针对急性心理应激会激活不同的生理途径。
