Herbert T B, Cohen S, Marsland A L, Bachen E A, Rabin B S, Muldoon M F, Manuck S B
Department of Psychology, Carnegie Mellon University, Pittsburgh, PA 15213.
Psychosom Med. 1994 Jul-Aug;56(4):337-44. doi: 10.1097/00006842-199407000-00009.
This study evaluated the temporal nature of cellular immune responses, as well as the effects of cardiovascular reactivity on immune responses after exposure to an acute psychological stressor. Lymphocyte subsets and lymphocyte proliferative response to phytohemagglutinin were assessed at baseline and at 5 and 21 minutes after stressor onset in the experimental group and at the same time points in a nonstressor control group. By 5 minutes after stressor onset, the number of CD8 suppressor/cytotoxic T and CD16/56 natural killer cells increased and proliferative response to phytohemagglutinin decreased. These changes were maintained at 21 minutes. Those subjects showing the greatest cardiovascular reactivity had the largest immune alterations. These data did not indicate that gender significantly moderated immune responses. Results are consistent with the hypothesis that sympathetic activation mediates stressor-induced quantitative alterations of peripheral blood lymphocyte subpopulations and nonspecific mitogen stimulated proliferation.
本研究评估了细胞免疫反应的时间特性，以及急性心理应激源暴露后心血管反应性对免疫反应的影响。在实验组应激源发作后的基线、5分钟和21分钟，以及在非应激对照组的相同时间点，评估淋巴细胞亚群和淋巴细胞对植物血凝素的增殖反应。应激源发作后5分钟，CD8抑制/细胞毒性T细胞和CD16/56自然杀伤细胞数量增加，对植物血凝素的增殖反应降低。这些变化在21分钟时持续存在。那些表现出最大心血管反应性的受试者免疫改变最大。这些数据并未表明性别显著调节免疫反应。结果与交感神经激活介导应激源诱导的外周血淋巴细胞亚群定量改变和非特异性有丝分裂原刺激增殖的假设一致。
