Rosner G L, Müller P
Department of Community and Family Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA.
J Pharmacokinet Biopharm. 1994 Dec;22(6):499-524. doi: 10.1007/BF02353792.
We discuss the analysis of the myelosuppressive effects of chemotherapy. Such analyses examine hematologic data that arise by monitoring patients after treatment with high doses of chemotherapy. We propose a flexible approach for modeling such information and, using data collected as part of a Phase I study of an anticancer agent, show some interesting aspects of the data that become available after fitting models this way.
