Mallet A, Mentré F, Steimer J L, Lokiec F
INSERM U194, Service d'Informatique Médicale, Paris, France.
J Pharmacokinet Biopharm. 1988 Jun;16(3):311-27. doi: 10.1007/BF01062140.
A new method, nonparametric maximum likelihood (NPML), for statistical analysis of population kinetic data is proposed. NPML provides a discrete estimate of the whole probability density function of the pharmacokinetic parameters. This permits a straightforward derivation of usual population characteristics. To illustrate the application of the NPML method, a population analysis of cyclosporine RIA measured plasma levels in 188 bone marrow transplant patients after intravenous infusion, is presented. The capability of NPML to extract population information from sparse individual data is also outlined.
提出了一种用于群体动力学数据统计分析的新方法——非参数最大似然法（NPML）。NPML提供了药代动力学参数整个概率密度函数的离散估计。这使得能够直接推导常见的群体特征。为了说明NPML方法的应用，本文给出了对188例骨髓移植患者静脉输注后环孢素放射免疫分析测定的血浆水平进行的群体分析。还概述了NPML从稀疏个体数据中提取群体信息的能力。
