Wang B, Zhou X Y
Department of Radiation Biology, Zoological Institute, School of Sciences, University of Tokyo, Japan.
J Radiat Res. 1995 Jun;36(2):103-11. doi: 10.1269/jrr.36.103.
Pregnant adult C57BL/6J mice, randomly assigned to 1 of 4 groups, 3 of them were irradiated with beta-rays from tritiated water (HTO) by a single intraperitoneal injection on the 12.5th day of gestation. Their offspring received cumulative doses of 0, 5, 10 or 30 cGy in utero. Male pups were trained and examined using a set of behavioral tests that included avoidance acquisition and avoidance maintenance, open field test, hole-board dipping, a water maze, and a food labyrinth. Results were found for most parameters in the 10 and 30 cGy groups that differed significantly from results for the controls, indicating that the behavioral teratogenic effect of prenatal exposure to chronic beta-ray radiation from HTO may be greater than the same dose of acute X- or gamma-irradiation and that 10 cGy may be the lowest detectable dose level at which behavioral changes is detactable under the conditions used in this experiment.
成年C57BL/6J怀孕小鼠被随机分为4组，其中3组在妊娠第12.5天通过单次腹腔注射接受来自氚水（HTO）的β射线照射。它们的后代在子宫内接受0、5、10或30 cGy的累积剂量。使用一组行为测试对雄性幼崽进行训练和检查，这些测试包括回避学习和回避维持、旷场试验、洞板试验、水迷宫试验和食物迷宫试验。在10 cGy和30 cGy组中，大多数参数的结果与对照组有显著差异，这表明产前暴露于HTO慢性β射线辐射的行为致畸效应可能大于相同剂量的急性X射线或γ射线辐射，并且在本实验所用条件下，10 cGy可能是可检测到行为变化的最低剂量水平。
