Bryant L R, des Rosier K F, Carpenter M T
Rheumatology Clinic, Wilford Hall Medical Center, Lackland AFB, TX 78236-5300, USA.
J Rheumatol. 1995 Aug;22(8):1527-31.
Hydroxychloroquine has been used successfully in the treatment of inflammatory arthritides such as rheumatoid arthritis and systemic lupus erythematosus, and less commonly in the seronegative spondyloarthropathies. Our objective was to determine the effectiveness of hydroxy-chloroquine in inflammatory or erosive osteoarthritis (OA).
We retrospectively reviewed clinical records of 8 patients prescribed hydroxychloroquine therapy whose symptoms of erosive OA were unresponsive to nonsteroidal antiinflammatory drugs (NSAID).
Hydroxychloroquine was effective in 6 of the 8 patients treated; it was well tolerated by all patients.
The use of hydroxychloroquine in patients with erosive OA unresponsive to NSAID appears promising. Prospective studies are needed to confirm our observations.
羟氯喹已成功用于治疗类风湿关节炎和系统性红斑狼疮等炎性关节炎，在血清阴性脊柱关节病中的应用较少。我们的目的是确定羟氯喹在炎性或侵蚀性骨关节炎（OA）中的疗效。
我们回顾性分析了8例接受羟氯喹治疗的患者的临床记录，这些患者的侵蚀性OA症状对非甾体抗炎药（NSAID）无反应。
8例接受治疗的患者中有6例对羟氯喹有效；所有患者对其耐受性良好。
在对NSAID无反应的侵蚀性OA患者中使用羟氯喹似乎前景良好。需要进行前瞻性研究来证实我们的观察结果。
