De Benedetti F, Massa M, Pignatti P, Kelley M, Faltynek C R, Martini A
Clinica Pediatrica, Università di Pavia, IRCCS Policlinico S. Matteo, Italy.
J Rheumatol. 1995 Aug;22(8):1581-5.
Since interleukin-7 (IL-7) has been shown to induce monocyte production of IL-1, IL-6, IL-8, and tumor necrosis factor-alpha, we investigated plasma and synovial fluid levels of IL-7 in patients with juvenile rheumatoid arthritis (JRA).
IL-7 levels were measured using an ELISA in 60 patients with JRA and in 25 patients with other rheumatic disorders (ORD).
In patients with systemic JRA, but not in patients with polyarticular or pauciarticular JRA or with ORD, plasma IL-7 levels were significantly higher (p < 0.0001) than those of healthy controls. IL-7 was undetected in all synovial fluid tested. Among patients with systemic JRA, those with persistent systemic symptoms had IL-7 levels significantly higher (p < 0.01) than those of patients in which systemic symptoms subsided.
Plasma IL-7 levels are elevated in patients with systemic JRA and are associated with the presence and severity of systemic symptoms.
鉴于白细胞介素-7（IL-7）已被证明可诱导单核细胞产生IL-1、IL-6、IL-8和肿瘤坏死因子-α，我们研究了幼年类风湿关节炎（JRA）患者血浆和滑液中IL-7的水平。
采用酶联免疫吸附测定法（ELISA）检测60例JRA患者和25例其他风湿性疾病（ORD）患者的IL-7水平。
全身型JRA患者的血浆IL-7水平显著高于健康对照组（p < 0.0001），而多关节型或少关节型JRA患者以及ORD患者则不然。所有检测的滑液中均未检测到IL-7。在全身型JRA患者中，有持续性全身症状的患者的IL-7水平显著高于全身症状消退的患者（p < 0.01）。
全身型JRA患者的血浆IL-7水平升高，且与全身症状的存在和严重程度相关。
