Nagashima Y, Ohno T, Ogawa K, Kuroshima A
Department of Physiology I, Asahikawa Medical College, Japan.
Jpn J Physiol. 1995;45(4):645-58. doi: 10.2170/jjphysiol.45.645.
To investigate the effects of fasting and refeeding on rat interscapular brown adipose tissue (BAT), we determined in vitro oxygen consumption, in vitro lipolysis, DNA content and composition of fatty acid (FA). Fasting decreased the weights of body and BAT, and the DNA content of BAT. Fasting reduced both basal oxygen consumption and basal lipolysis of BAT. Fasting also suppressed the noradrenaline- and glucagon-induced increases in both oxygen consumption and lipolysis of BAT. In both triglyceride and phospholipid FA of BAT the extent of unsaturation was increased by fasting. Refeeding restored all of these parameters to the control level. These observations indicate that fasting reduces both oxygen consumption and lipolysis of BAT, resulting in reduced thermogenesis, while fasting could stimulate BAT in certain phases of its function as observed in FA composition.
为研究禁食和再喂养对大鼠肩胛间棕色脂肪组织（BAT）的影响，我们测定了体外氧消耗、体外脂肪分解、DNA含量以及脂肪酸（FA）组成。禁食降低了体重和BAT重量，以及BAT的DNA含量。禁食减少了BAT的基础氧消耗和基础脂肪分解。禁食还抑制了去甲肾上腺素和胰高血糖素诱导的BAT氧消耗和脂肪分解增加。在BAT的甘油三酯和磷脂FA中，禁食均增加了不饱和程度。再喂养使所有这些参数恢复到对照水平。这些观察结果表明，禁食减少了BAT的氧消耗和脂肪分解，导致产热减少，而如在FA组成中所观察到的，禁食在其功能的某些阶段可刺激BAT。
