Yoshikawa K, Hirose S, Sasamoto Y, Kotake S, Matsuda H
Department of Opthalmology, Hokkaido University School of Medicine, Japan.
Jpn J Ophthalmol. 1995;39(4):347-52.
It is known that the susceptibility to experimental autoimmune uveitis (EAU) is controlled by both major histocompatibility antigen complex (MHC) and non-MHC genes. In this report, we studied the role of non-MHC genes in the induction of EAU. LEW, WKAH, (LEW x WKAH)F1, and (LEW x WKAH)F2 rats were examined to determine the incidence and severity of EAU induced by immunization with bovine S-antigen (S-Ag). We found that all the LEW rats developed severe EAU within 2 weeks after immunization, but no WKAH rats did. Most of the F1 rats developed mild inflammation in 3-4 weeks after immunization. A quarter of the F2 rats developed EAU within 2 weeks, half of them, in 3-6 weeks after immunization, and the others did not. These findings suggest that only one non-MHC gene controls the susceptibility to S-Ag-induced EAU in rats.
已知实验性自身免疫性葡萄膜炎（EAU）的易感性由主要组织相容性抗原复合体（MHC）和非MHC基因共同控制。在本报告中，我们研究了非MHC基因在EAU诱导中的作用。对LEW、WKAH、（LEW×WKAH）F1和（LEW×WKAH）F2大鼠进行检查，以确定用牛S抗原（S-Ag）免疫诱导的EAU的发病率和严重程度。我们发现，所有LEW大鼠在免疫后2周内都出现了严重的EAU，但没有WKAH大鼠出现。大多数F1大鼠在免疫后3-4周出现轻度炎症。四分之一的F2大鼠在免疫后2周内出现EAU，其中一半在免疫后3-6周出现，其余的则没有。这些发现表明，只有一个非MHC基因控制大鼠对S-Ag诱导的EAU的易感性。
