Fairley C K, Smoleniec J S, Caul O E, Miller E
Public Health Laboratory Service, Communicable Disease Surveillance Centre, London, UK.
Lancet. 1995 Nov 18;346(8986):1335-7. doi: 10.1016/s0140-6736(95)92346-2.
The role of intrauterine transfusion for fetal hydrops arising from maternal paravirus B19 infection is unclear. 66 cases of fetal hydrops arising from B19 infection were reported in England and Wales between June, 1992, and September, 1994. In 29 cases the fetus was dead at the time of the first abnormal ultrasound or a therapeutic abortion as performed; 12 of the 38 alive at the first abnormal scan received intrauterine transfusions and 3 of the 12 died. 26 did not receive intrauterine transfusions and 13 died. After adjustment for the severity of the hydrops as assessed by the ultrasound and for gestational age, the odds of death among those who received an intrauterine transfusion was significantly less than among those who did not (odds ratio 0.14, 95% CI 0.02-0.96). These findings suggest that intrauterine transfusion will benefit some fetuses with hydrops arising from parvovirus B19 infection.
宫内输血对由孕妇感染细小病毒B19引起的胎儿水肿的作用尚不清楚。1992年6月至1994年9月期间，英格兰和威尔士报告了66例由B19感染引起的胎儿水肿病例。在29例病例中，胎儿在首次超声检查异常时已死亡或已实施治疗性流产；在首次超声检查异常时存活的38例中，12例接受了宫内输血，其中3例死亡。26例未接受宫内输血，13例死亡。在根据超声评估的水肿严重程度和胎龄进行调整后，接受宫内输血者的死亡几率显著低于未接受者（优势比0.14，95%可信区间0.02 - 0.96）。这些发现表明，宫内输血将使一些由细小病毒B19感染引起水肿的胎儿受益。
