Odibo A O, Campbell W A, Feldman D, Ling P Y, Leo M V, Borgida A F, Rodis J F
Department of Obstetrics and Gynecology, University of Connecticut Health Center, Farmington, USA.
J Ultrasound Med. 1998 Sep;17(9):547-50. doi: 10.7863/jum.1998.17.9.547.
Our objective is to report our experience with cases of prolonged recovery from nonimmune hydrops secondary to human parvovirus B19 infection occurring after intrauterine transfusion. We reviewed cases referred to our unit over a 10 year period for exposure to parvovirus B19 infection. Those cases with serologic evidence of recent infection were identified. The cases requiring intrauterine transfusion were reviewed for demographic details, time of exposure, parvovirus B19 serology, gestational age at detection of nonimmune hydrops, number and results of fetal blood samples, duration from intrauterine transfusion to resolution of hydrops, and neonatal outcome. Of 38 cases identified through serologic evidence of recent parvovirus B19 infection, 35 (92.1%) did not develop hydrops, and these were followed by serial ultrasonography for 8 weeks from the time of exposure. Three cases (7.9%) developed hydrops and required intrauterine transfusion; in two the transfusion was intravascular and in one it was intraperitoneal. The mean duration from intrauterine transfusion to resolution of hydrops was 8 weeks 2 days. Pregnancy outcome in all cases was normal. In cases of nonimmune hydrops secondary to parvovirus B19 infection, resolution of the hydrops after intrauterine transfusion may take up to 12 weeks with a normal pregnancy outcome.
我们的目的是报告经宫内输血后因人类细小病毒B19感染继发非免疫性水肿而恢复时间延长的病例的相关经验。我们回顾了在10年期间转诊至我单位的暴露于细小病毒B19感染的病例。确定那些有近期感染血清学证据的病例。对需要宫内输血的病例进行人口统计学细节、暴露时间、细小病毒B19血清学、检测到非免疫性水肿时的孕周、胎儿血样数量及结果、从宫内输血到水肿消退的持续时间以及新生儿结局等方面的审查。在通过近期细小病毒B19感染血清学证据确定的38例病例中，35例（92.1%）未出现水肿，从暴露时起对这些病例进行了为期8周的系列超声检查。3例（7.9%）出现水肿并需要宫内输血；2例为血管内输血，1例为腹腔内输血。从宫内输血到水肿消退的平均持续时间为8周零2天。所有病例的妊娠结局均正常。在因细小病毒B19感染继发非免疫性水肿的病例中，宫内输血后水肿消退可能需要长达12周时间，妊娠结局正常。
