Suemaru S, Suemaru K, Kawai K, Miyata S, Nobukuni K, Ihara Y, Namba R, Urakami K, Hashimoto K
Department of Psychogeriatrics and Psychoneuroendocrinology, Hiroshima, Japan.
Life Sci. 1995;57(24):2231-5. doi: 10.1016/0024-3205(95)02215-5.
Levels of corticotropin-releasing hormone (CRH) in cerebrospinal fluid (CSF) were examined in patients with spinocerebellar degeneration (SCD) including olivopontocerebellar atrophy (OPCA), dentatorubropallidoluysian atrophy (DRPLA) and Friedreich's ataxia, Parkinson's disease (PD) and senile dementia of the Alzheimer type (SDAT), and normal aged subjects. CRH concentrations in CSF were significantly reduced in SCD compared to SDAT, PD and CSF and normal aged subjects. It is likely that degeneration not only of the cerebral cortex and the limbic system but also of the subcortical structures such as the brainstem and the cerebellum alters levels of CRH in CSF. Together with the recent anatomical and physiological evidence, the results suggest pathophysiological relevance of CRH for the cerebellar symptoms in SCD.
对患有脊髓小脑变性（SCD）的患者，包括橄榄脑桥小脑萎缩（OPCA）、齿状核红核苍白球路易体萎缩（DRPLA）和弗里德赖希共济失调、帕金森病（PD）和阿尔茨海默型老年痴呆症（SDAT）的患者以及正常老年受试者的脑脊液（CSF）中促肾上腺皮质激素释放激素（CRH）水平进行了检测。与SDAT、PD和正常老年受试者相比，SCD患者脑脊液中CRH浓度显著降低。很可能不仅大脑皮层和边缘系统的退化，而且脑干和小脑等皮层下结构的退化都会改变脑脊液中CRH的水平。结合最近的解剖学和生理学证据，结果表明CRH与SCD中的小脑症状存在病理生理相关性。
