Nitrite, nitrate and cGMP in the cerebrospinal fluid in degenerative neurologic diseases.
作者信息
Ikeda M, Sato I, Yuasa T, Miyatake T, Murota S
机构信息
Department of Physiological Chemistry, Graduate School, Tokyo Medical and Dental University, Japan.
出版信息
J Neural Transm Gen Sect. 1995;100(3):263-7. doi: 10.1007/BF01276464.
PMID:8748672
Abstract
To investigate whether nitric oxide (NO) plays a role in degenerative neurologic disease (DND), we measured nitrite, nitrate and cyclic GMP in cerebrospinal fluid (CSF) samples from patients with Parkinson's disease (PD), spinocerebellar ataxia (SCA) and amyotrophic lateral sclerosis (ALS). We found no significant change in CSF nitrite, nitrate or cyclic GMP in patients with any DND compared with control values. These results suggest that NO production is preserved in PD, SCA and ALS.
摘要
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