Berche P
INSERM U 411, Faculté de Médecine Necker-Enfants Malades, Paris, France.
Microb Pathog. 1995 May;18(5):323-36. doi: 10.1006/mpat.1995.0029.
The ability of the facultative intracellular pathogen Listeria monocytogenes to penetrate the central nervous system (CNS) was studied by following the kinetics of brain invasion and histological lesions during an acute intravenous (i.v.) infection in the mouse. CNS invasion occurred during the early phase of infection and produced severe meningoencephalitis characterized by multiple granulomatous foci predominantly located in the brainstem and associated with diffuse meningitis and an intense inflammatory reaction involving the choroid plexuses. Bacterial counts in the brain could reach 10(4.5)-10(5.8) by day 5 of infection with 1-2 x 10(6) bacteria i.v., depending upon the bacterial strain used. It was found that CNS invasion was highly dependent upon the level and the duration of bacteremia, thus indicating that persistent bacteremia is essential to induce meningoencephalitis to L. monocytogenes.
通过追踪小鼠急性静脉注射感染期间脑侵袭动力学和组织学损伤，研究了兼性细胞内病原体单核细胞增生李斯特菌穿透中枢神经系统（CNS）的能力。CNS侵袭发生在感染早期，导致严重的脑膜脑炎，其特征是多个肉芽肿病灶主要位于脑干，并伴有弥漫性脑膜炎以及涉及脉络丛的强烈炎症反应。静脉注射1 - 2×10⁶个细菌，感染第5天时，根据所用细菌菌株的不同，脑内细菌计数可达10⁽⁴·⁵⁾ - 10⁽⁵·⁸⁾。研究发现，CNS侵袭高度依赖于菌血症的水平和持续时间，这表明持续性菌血症对于诱导单核细胞增生李斯特菌引起脑膜脑炎至关重要。
