血管升压素、血管紧张素和催产素对肝细胞悬液中糖异生的刺激作用。
Stimulation by vasopressin, angiotensin and oxytocin of gluconeogenesis in hepatocyte suspensions.
作者信息
Whitton P D, Rodrigues L M, Hems D A
出版信息
Biochem J. 1978 Dec 15;176(3):893-8. doi: 10.1042/bj1760893.
Abstract
- In hepatocytes from starved rats, vasopressin, angiotensin (angiotensin II) and oxytocin stimulated gluconeogenesis from lactate by 25--50%; minimal effective concentrations were about 0.02pM, 1 nM and 0.2 nM respectively. 2. Vasopressin and angiotensin also stimulated gluconeogenesis from alanine, pyruvate, serine and glycerol. EGTA decreased gluconeogenesis from these substrates. 3. Hormonal stimulation of gluconeogenesis from lactate was abolished in the absence of extracellular Ca2+. 4. Insulin did not prevent stimulation of gluconeogenesis by vasopressin or angiotensin. 5. The potency of the stimulatory effects of vasopressin and angiotensin on hepatic gluconeogenesis suggests they are operative in vivo. Also, the data suggest that Ca2+ plays a role in the stimulation by these hormones.
摘要
- 在饥饿大鼠的肝细胞中，血管升压素、血管紧张素（血管紧张素II）和催产素可使乳酸生成葡萄糖的糖异生作用增强25% - 50%；最小有效浓度分别约为0.02皮摩尔、1纳摩尔和0.2纳摩尔。2. 血管升压素和血管紧张素还能刺激丙氨酸、丙酮酸、丝氨酸和甘油生成葡萄糖。乙二醇双（2-氨基乙基醚）四乙酸（EGTA）可减少这些底物的糖异生作用。3. 在没有细胞外钙离子的情况下，激素对乳酸糖异生的刺激作用消失。4. 胰岛素不能阻止血管升压素或血管紧张素对糖异生的刺激作用。5. 血管升压素和血管紧张素对肝脏糖异生的刺激作用强度表明它们在体内发挥作用。此外，数据表明钙离子在这些激素的刺激作用中起作用。
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