Perinatal and Cardiovascular Epidemiology, Department of Clinical Sciences in Malmö, Lund University, Malmö, Sweden.
Department of Internal Medicine, Skåne University Hospital, Malmö, Sweden.
J Intern Med. 2022 Aug;292(2):365-376. doi: 10.1111/joim.13489. Epub 2022 Apr 17.
Vasopressin concentration is typically higher at night, during stress, and in males, but readily lowered by water intake. Vasopressin is also a causal candidate for cardiometabolic disease, which shows seasonal variation.
To study whether vasopressin concentration varies by season in a temperate climate.
The vasopressin surrogate marker copeptin was analyzed in fasting plasma samples from five population-based cohorts in Malmö, Sweden (n = 25,907, 50.4% women, age 18-86 years). We investigated seasonal variation of copeptin concentration and adjusted for confounders in sinusoidal models.
The predicted median copeptin level was 5.81 pmol/L (7.18 pmol/L for men and 4.44 pmol/L for women). Copeptin exhibited a distinct seasonal pattern with a peak in winter (mid-February to mid-March) and nadir in late summer (mid-August to mid-September). The adjusted absolute seasonal variation in median copeptin was 0.62 pmol/L (95% confidence interval [CI] 0.50; 0.74, 0.98 pmol/L [95% CI 0.73; 1.23] for men and 0.46 pmol/L [95% CI 0.33; 0.59] for women). The adjusted relative seasonal variation in mean log copeptin z-score was 0.20 (95% CI 0.17; 0.24, 0.18 [95% CI 0.14; 0.23] in men and 0.24 [95% CI 0.19; 0.29] in women). The observed seasonal variation of copeptin corresponded to a risk increase of 4% for incident diabetes mellitus and 2% for incident coronary artery disease.
The seasonal variation of the vasopressin marker copeptin corresponds to increased disease risk and mirrors the known variation in cardiometabolic status across the year. Moderately increased water intake might mitigate the winter peak of cardiometabolic disease.
加压素浓度通常在夜间、应激和男性中较高，但通过饮水很容易降低。加压素也是心血管代谢疾病的候选原因，该疾病具有季节性变化。
研究在温带气候中加压素浓度是否随季节变化。
分析了来自瑞典马尔默的五个基于人群的队列的空腹血浆样本中的加压素替代标志物 copeptin（n=25907 人，50.4%为女性，年龄 18-86 岁）。我们调查了 copeptin 浓度的季节性变化，并在正弦模型中调整了混杂因素。
预测中位 copeptin 水平为 5.81 pmol/L（男性为 7.18 pmol/L，女性为 4.44 pmol/L）。copeptin 表现出明显的季节性模式，峰值出现在冬季（2 月中旬至 3 月中旬），低谷出现在夏季末（8 月中旬至 9 月中旬）。中位 copeptin 的调整后绝对季节性变化为 0.62 pmol/L（95%置信区间[CI]：0.50-0.74，0.98 pmol/L[95% CI：0.73-1.23]）男性和 0.46 pmol/L（95% CI：0.33-0.59）女性）。平均对数 copeptin z 分数的调整后相对季节性变化为 0.20（95% CI：0.17-0.24，0.18[95% CI：0.14-0.23]）男性和 0.24（95% CI：0.19-0.29）女性）。copeptin 的观察到的季节性变化对应于糖尿病和冠心病事件风险增加 4%和 2%。
加压素标志物 copeptin 的季节性变化与疾病风险增加相对应，反映了心血管代谢状态全年的已知变化。适度增加水的摄入可能会减轻心血管代谢疾病冬季高峰的发生。
