Stute Nina L, Linder Braxton A, Sanchez Sofia O, Vondrasek Joseph D, Cross Brett, Tharpe McKenna A, Hutchison Zach J, Pangelinan Melissa, Muñoz Colleen X, Grosicki Gregory J, Fuller-Rowell Thomas, Robinson Austin T
Neurovascular Physiology Laboratory, School of Kinesiology, Auburn University, Auburn, AL, USA.
Neurovascular Physiology Laboratory, School of Kinesiology, Auburn University, Auburn, AL, USA; Department of Kinesiology, School of Public Health, Indiana University, Bloomington, IN, USA.
Nutr Res. 2025 Apr;136:81-93. doi: 10.1016/j.nutres.2025.02.007. Epub 2025 Mar 6.
Underhydration is associated with higher plasma copeptin concentration ([copeptin]), an arginine vasopressin surrogate associated with multiple chronic diseases. Middle-aged and older Black individuals are more likely to be underhydrated and exhibit higher [copeptin] than White individuals. However, limited data exists on racial differences in [copeptin] in young adults. Therefore, we tested the hypothesis that apparently healthy young Black adults would report lower fluid intake and exhibit higher plasma [copeptin] than young White adults. Participants (n = 86; sex: 40F/46M; race: White n = 48, Black n = 38; age: 21±2 years, BMI: 25±4 kg/m) completed 3-day food and fluid diaries. We operationalized beverages into 8 categories (water, sugar-sweetened beverages, milk/non-dairy alternatives, juice, nonaloric beverages (eg, diet drinks), coffee or tea (noncaloric), coffee or tea (caloric), and alcohol) and measured plasma [copeptin]. We assessed racial differences in fluid intake and [copeptin] and also examined relations between race, fluid intake, and [copeptin] via regression and correlation analyses. Compared with White adults, Black adults consumed less total fluid (64.0[31.3] vs. 89.7[53.6] oz), water, alcohol, and coffee/tea (noncaloric and caloric) but more juice (ps < .05). Black participants exhibited higher plasma [copeptin] (6.38[4.83] vs. 4.45[2.92] pmol/L, P = .021). In the whole cohort, plasma [copeptin] was negatively correlated with water intake (ρ= -0.249, P = .021). However, racial differences in [copeptin] were attenuated by 27% when accounting for total fluid intake. Black young adults reported lower fluid intake and exhibited higher plasma [copeptin] than White young adults. Interventions are needed to address racial disparities in hydration practices, potentially attenuating racial differences in [copeptin] and related health disparities.
水分摄入不足与较高的血浆 copeptin 浓度（[copeptin]）相关，copeptin 是一种与多种慢性疾病相关的精氨酸加压素替代物。中年及老年黑人比白人更易出现水分摄入不足且 [copeptin] 水平更高。然而，关于年轻成年人中 [copeptin] 的种族差异的数据有限。因此，我们检验了这样一个假设：明显健康的年轻黑人成年人比年轻白人成年人报告的液体摄入量更低，且血浆 [copeptin] 水平更高。参与者（n = 86；性别：40 名女性/46 名男性；种族：白人 n = 48，黑人 n = 38；年龄：21±2 岁，体重指数：25±4 kg/m²）完成了为期 3 天的食物和液体日记。我们将饮料分为 8 类（水、含糖饮料、牛奶/非乳制品替代品、果汁、无热量饮料（如减肥饮料）、咖啡或茶（无热量）、咖啡或茶（含热量）以及酒精）并测量血浆 [copeptin]。我们评估了液体摄入量和 [copeptin] 的种族差异，并通过回归和相关分析研究了种族、液体摄入量和 [copeptin] 之间的关系。与白人成年人相比，黑人成年人的总液体摄入量更少（64.0[31.3] 盎司对 89.7[53.6] 盎司），水、酒精以及咖啡/茶（无热量和含热量）的摄入量也更少，但果汁摄入量更多（p 值 <.05）。黑人参与者的血浆 [copeptin] 水平更高（6.38[4.83] 对 4.45[2.92] pmol/L，P =.021）。在整个队列中，血浆 [copeptin] 与水的摄入量呈负相关（ρ = -0.249，P =.021）。然而，在考虑总液体摄入量后，[copeptin] 的种族差异减弱了 27%。年轻黑人成年人报告的液体摄入量低于年轻白人成年人，且血浆 [copeptin] 水平更高。需要采取干预措施来解决水分摄入方面的种族差异，这可能会减弱 [copeptin] 的种族差异以及相关的健康差异。
