Colella G, De Luca F, Lanza A, Tartaro G P
Istituto di Chirurgia Orale e Maxillo-Facciale, Seconda Università degli Studi, Napoli.
Minerva Stomatol. 1995 Jun;44(6):291-300.
After considering the leukoplakia as defined by the WHO, the authors examine the quantitative, qualitative, histopathologic and clinical aspects of leukoplastic lesions. Afterwards, the data concerning the incidence of the malignant evolution of leukoplakia are shown. Data that have been collected and shown during years of study and that are often discordant. For this reason a study on the literature since 1931 is carried out and all the possible causes that could have led to different results are mentioned. Than the authors, among 98 cases of leukoplakia, examine those that turned malignant. In five cases, after the first biopsy, the histopathological report found the presence of microcarcinoma while, in three other cases, in the follow-up, a malignant evolution was observed. This This study points out a percentage of malignant transformation of the leukoplakia equal to 2,94% in agreement with the study of Pindborg and Banoczy.
在考虑了世界卫生组织定义的白斑之后，作者们研究了白斑病变的定量、定性、组织病理学和临床方面。之后，展示了有关白斑恶性演变发生率的数据。这些数据是在多年研究中收集并展示的，且常常不一致。因此，对1931年以来的文献进行了一项研究，并提及了所有可能导致不同结果的原因。然后，作者们在98例白斑病例中，检查了那些发生恶变的病例。在5例中，首次活检后组织病理学报告发现存在微癌，而在另外3例中，在随访中观察到了恶性演变。这项研究指出白斑的恶性转化率为2.94%，这与平德伯格和巴诺茨的研究结果一致。
