Ghoneim M M, Van Hamme M J
Br J Anaesth. 1978 Dec;50(12):1237-42. doi: 10.1093/bja/50.12.1237.
Plasma concentrations of thiopentone following the injection of 3.5 mg kg-1 i.v. were studied in six patients who received enflurane and nitrous oxide anaesthesia and six volunteers. We identified a three-compartment open model system containing both a "shallow" and a "deep" peripheral compartment in all the patients and half of the controls, and a two-compartment open model for the remaining volunteers. The distribution of thiopentone to the tissues was very rapid, the alpha and beta distribution half-lives averaging 2.5 min and 46.4 min respectively for the patient group and 2.8 min and 48.7 min for the control group. The wide distribution of the drug was indicated by the apparent volume of distribution, the means of which varied between 2 and 1.5 times body weight. The mean elimination half-life was 5.1 h for the patients and 5.7 h for the volunteers. The return of the drug to the central compartment from the deep peripheral compartment was the rate-controlling factor in its elimination. Neither enflurane and nitrous oxide anaesthesia nor the stress of surgery affected the distribution or clearance of the drug from plasma.
在六名接受恩氟烷和氧化亚氮麻醉的患者以及六名志愿者中，研究了静脉注射3.5毫克/千克硫喷妥钠后的血浆浓度。我们在所有患者和一半的对照组中确定了一个三室开放模型系统，该系统包含一个“浅”外周室和一个“深”外周室，其余志愿者为二室开放模型。硫喷妥钠向组织的分布非常迅速，患者组的α和β分布半衰期平均分别为2.5分钟和46.4分钟，对照组为2.8分钟和48.7分钟。药物的广泛分布通过分布容积来表明，其平均值在体重的2至1.5倍之间变化。患者的平均消除半衰期为5.1小时，志愿者为5.7小时。药物从深外周室返回中央室是其消除的速率控制因素。恩氟烷和氧化亚氮麻醉以及手术应激均未影响药物在血浆中的分布或清除。
