Claas E C, de Jong J C, Bartelds A I, Rimmelzwaan G F, van Wijngaarden J K, Osterhaus A D
National Influenza Centrum van de WHO, Erasmus Universiteit, afd. Virologie, Rotterdam.
Ned Tijdschr Geneeskd. 1995 Oct 21;139(42):2154-8.
The 1994/'95 season in the Netherlands was marked by a limited influenza activity which only emerged in late February. The influenza activity remained elevated until the end of April, which is unusually late, and epidemic activity was only reported in the south of the country. Both influenza A/H3N2 and B viruses were isolated in this period. In addition, influenza A/HINI viruses were isolated for the first time since March 1993, from two patients. The majority of the influenza A strains that circulated in the Netherlands in 1994/'95 reacted well with ferret antiserum raised against the strains of the 1994/'95 influenza vaccine, which therefore probably offered good protection. The reactivity of the B strains to antiserum raised against the vaccine strain, B/Panama/45/90, was only moderate, which implies that the protection against the Dutch influenza B strains was not optimal. Based on the results of the worldwide influenza surveillance, the World Health Organization (WHO) has recommended an alteration in both the A/H3N2 and the B component for the vaccine of 1995/1996.
1994/95年荷兰流感季的特点是流感活动有限，且直到2月下旬才出现。流感活动一直持续到4月底，这一情况异乎寻常地晚，且仅在该国南部报告有疫情活动。在此期间，A型H3N2流感病毒和B型流感病毒均被分离出来。此外，自1993年3月以来，首次从两名患者身上分离出A型H1N1流感病毒。1994/95年在荷兰传播的大多数A型流感毒株与针对1994/95年流感疫苗毒株产生的雪貂抗血清反应良好，因此该疫苗可能提供了良好的保护。B型毒株与针对疫苗毒株B/巴拿马/45/90产生的抗血清的反应仅为中等程度，这意味着针对荷兰B型流感毒株的保护并非最佳。基于全球流感监测结果，世界卫生组织（WHO）建议对1995/1996年疫苗的A型H3N2和B型成分都进行更改。
