Lamont P, Murray N, Halliday G, Hilton J, Pamphlett R
Department of Pathology (Neuropathology Division), University of Sydney, Australia.
Neuropathol Appl Neurobiol. 1995 Jun;21(3):262-8. doi: 10.1111/j.1365-2990.1995.tb01058.x.
It has been suggested that the defect underlying the sudden infant death syndrome (SIDS) lies in brain stem nuclei involved in cardiac and respiratory function. However, most studies have not used rigorous quantitative techniques to assess brain stem nuclear volumes and neuronal numbers. We have measured the volume, neuronal numbers and position of brain stem nuclei in 11 SIDS and 11 aged-matched control infants. Using serial sagittal sections, nuclei involved in maintaining airway patency (hypoglossal, ambiguus and retroambiguus), heart rate (dorsal vagal) and generation of respiratory rhythm (ambiguus and dorsal vagal) were studied. No significant differences were found in nuclear volume increase with age, total neuronal number or nuclear position between SIDS and control cases. These findings support the hypothesis that the nervous system in SIDS may be normal until the final event that kills these infants.
有人提出，婴儿猝死综合征（SIDS）潜在的缺陷在于参与心脏和呼吸功能的脑干核团。然而，大多数研究并未采用严格的定量技术来评估脑干核团的体积和神经元数量。我们测量了11例SIDS婴儿和11例年龄匹配的对照婴儿脑干核团的体积、神经元数量和位置。利用连续矢状切片，研究了参与维持气道通畅（舌下神经核、疑核和后疑核）、心率（迷走神经背核）和呼吸节律产生（疑核和迷走神经背核）的核团。在SIDS病例和对照病例之间，未发现核团体积随年龄增加、总神经元数量或核团位置有显著差异。这些发现支持了这样一种假说，即直到导致这些婴儿死亡的最终事件发生之前，SIDS婴儿的神经系统可能都是正常的。
