Takashima S, Mito T, Yamanouchi H
Division of Mental Retardation and Birth Defect Research, National Center of Neurology and Psychiatry, Tokyo, Japan.
Acta Paediatr Jpn. 1994 Jun;36(3):317-20. doi: 10.1111/j.1442-200x.1994.tb03191.x.
The brain-stems of control and sudden infant death syndrome (SIDS) infants were examined developmentally with Golgi and immunohistochemical methods. The development of dendritic spines changed dramatically from the prenatal to postnatal period in the ventrolateral medulla as well as in the reticular formation and vagal nuclei in controls, but persisted in SIDS infants. These observations suggest a delay in maturation of the meduallary respiratory neurons and transneuronal connection between the central chemoreceptor and neural respiratory center in SIDS. In addition, substance P (SP)-positive nerve fibers were increased in the pons of SIDS infants. An increased activity in the afferent SP neurons in SIDS may be due to chronic hypoxia as in brain-stem gliosis, and may be involved in cardiorespiratory regulation.
采用高尔基染色法和免疫组织化学方法对对照婴儿和婴儿猝死综合征（SIDS）婴儿的脑干进行发育研究。在对照组中，从产前到产后，腹外侧延髓以及网状结构和迷走神经核中的树突棘发育发生了显著变化，但在SIDS婴儿中这种变化持续存在。这些观察结果表明，SIDS婴儿的延髓呼吸神经元成熟延迟，且中枢化学感受器与神经呼吸中枢之间的跨神经元连接存在延迟。此外，SIDS婴儿脑桥中P物质（SP）阳性神经纤维增加。SIDS中传入SP神经元活性增加可能是由于脑干胶质增生那样的慢性缺氧所致，并且可能参与心肺调节。
