Komorowski J, Stepień H
Institute of Endocrinology, Medical University of Lódz, Poland.
Neuropeptides. 1995 Aug;29(2):77-81. doi: 10.1016/0143-4179(95)90087-x.
Recent evidence has revealed that various neuropeptides appear to have distinct roles as immunomodulators. The aim of this study was to evaluate the role of hypothalamic neuropeptides (thyreoliberin [TRH], somatostatin [SRIF], and gonadoliberin [LH-RH]) on the secretion of interleukin-1 beta (IL-1 beta) and interleukin-6 (IL-6) from lipopolysaccharide (LPS) activated human peripheral blood monocytes (PM) cultured in vitro. LPS in concentration 1.5 micrograms/ml stimulated PBM to release IL-1 beta or IL-6 into the supernatants. SRIF in concentrations from 10(-8)M to 10(-10)M (but neither RH nor LH-RH in the same concentrations) potentiated the release of IL-6 from PBM. None of the tested neuropeptides stimulated the release of IL-1 beta from LPS activated human monocytes. These data indicate that SRIF in physiological or pharmacological concentrations which activate the release of IL-6 from PBM may be one of the regulators of immune response in humans.
最近的证据表明，各种神经肽似乎作为免疫调节剂具有不同的作用。本研究的目的是评估下丘脑神经肽（促甲状腺激素释放激素[TRH]、生长抑素[SRIF]和促性腺激素释放激素[LH-RH]）对体外培养的脂多糖（LPS）激活的人外周血单核细胞（PM）分泌白细胞介素-1β（IL-1β）和白细胞介素-6（IL-6）的作用。浓度为1.5微克/毫升的LPS刺激外周血单核细胞向培养上清液中释放IL-1β或IL-6。浓度为10^(-8)M至10^(-10)M的SRIF（但相同浓度的TRH和LH-RH均无此作用）增强了外周血单核细胞释放IL-6的能力。所测试的神经肽均未刺激LPS激活的人单核细胞释放IL-1β。这些数据表明，生理或药理浓度的SRIF激活外周血单核细胞释放IL-6，可能是人类免疫反应的调节因子之一。
