Dörsam J, Knopp M V, Schad L, Piesche S, Carl S, Oesingmann N
Department of Urology, University of Heidelberg, Germany.
Nephrol Dial Transplant. 1995;10(7):1228-30.
Magnetic resonance urography (MRU) after i.v. injection of gadolinium-DTPA (0.1 mmol/kg bodyweight) was performed in a patient with transplant dysfunction after renal allograft transplantation. Renal replacement therapy was accomplished by means of peritoneal dialysis. Gadolinium-DTPA concentrations in urine and dialysate were measured repeatedly during a 48-h period with inductively coupled plasma atomic emission spectrometry. The total 24-h creatinine clearance was 10.8 ml/min on day 1 and 13.7 ml/min on day 2. The corresponding total gadolinium clearance was 12.8 ml/min and 15.8 ml/min respectively. Gadolinium-DTPA was removed from the body through peritoneal dialysis at a mean clearance rate of 5.13 ml/min. Plasma half-life of gadolinium-DTPA was prolonged to 9 h. No side-effects due to gadolinium-DTPA were noted. MRU provided a better visualization of the morphology of the urinary tract than scintigraphic studies. By measuring the changes of signal intensity, the gadolinium excretion could be calculated.
对一名肾移植后出现移植肾功能障碍的患者，静脉注射钆喷酸葡胺（0.1 mmol/kg体重）后进行了磁共振尿路造影（MRU）检查。通过腹膜透析进行肾脏替代治疗。在48小时内，用感应耦合等离子体原子发射光谱法反复测量尿液和透析液中的钆喷酸葡胺浓度。第1天的24小时肌酐清除率总量为10.8 ml/min，第2天为13.7 ml/min。相应的钆总量清除率分别为12.8 ml/min和15.8 ml/min。钆喷酸葡胺通过腹膜透析以平均5.13 ml/min的清除率从体内清除。钆喷酸葡胺的血浆半衰期延长至9小时。未观察到钆喷酸葡胺引起的副作用。与闪烁扫描研究相比，MRU能更好地显示尿路形态。通过测量信号强度的变化，可以计算出钆的排泄情况。
