Schubert V, Schubert P A, Breit G, Intaglietta M
Department of Clinical Neuroscience and Family Medicine, Karolinska Institutet, Huddinge University Hospital, Sweden.
Paraplegia. 1995 Jul;33(7):387-97. doi: 10.1038/sc.1995.88.
Flowmotion (blood flow changes due to vasomotion) in the skin over a risk area for pressure sores, the sacrum, and a non-risk area, the gluteus muscle, was evaluated by laser Doppler fluxmetry during resting conditions and post-occlusive reactive hyperaemia (PRH) response. Measurements were made in healthy younger subjects and in two risk groups for pressure sores-spinal cord injured (SCI) and the elderly. The SCI were divided into two subgroups, one with and one without distinct flowmotion seen on the original recordings over the sacrum. The Prony spectral line estimation (PSLE) method was used to determine the power spectrum of the flowmotion activity. During the PRH, flowmotion frequencies were found in two separated bands, 5.4-6.6 cpm (cycles min-1) and 7.8-9.0 cpm. In the subgroup without distinct flowmotion, the PSLE method found flowmotion frequencies similar to the other groups. During the PRH, the flowmotion power pattern over the sacrum was similar within all groups, but the power was extremely low in one subgroup of SCI subjects. To conclude, flowmotion (vasomotion) was present in the two skin areas and increased during the PRH response, reaching a maximum within 50 s. This study shows that the flowmotion frequencies might be locally driven, whereas the power might be centrally mediated. Disturbances in microcirculatory flowmotion can be a part of the mechanisms leading to skin ischaemia and pressure sores. A new method has been developed for analysing differences in flowmotion behaviour such that statistical comparisons can be made.
在静息状态和闭塞后反应性充血（PRH）反应期间，通过激光多普勒血流仪评估了骶骨（压疮风险区域）和臀肌（非风险区域）皮肤中的血流运动（由于血管运动引起的血流变化）。对健康的年轻受试者以及两个压疮风险组——脊髓损伤（SCI）患者和老年人进行了测量。SCI患者被分为两个亚组，一组在骶骨区域的原始记录中可见明显的血流运动，另一组则没有。使用 Prony 谱线估计（PSLE）方法来确定血流运动活动的功率谱。在PRH期间，发现血流运动频率存在于两个分开的频段，即5.4 - 6.6次/分钟（每分钟周期数）和7.8 - 9.0次/分钟。在没有明显血流运动的亚组中，PSLE方法发现的血流运动频率与其他组相似。在PRH期间，所有组中骶骨区域的血流运动功率模式相似，但在一组SCI受试者中功率极低。总之，两个皮肤区域均存在血流运动（血管运动），并且在PRH反应期间增加，在50秒内达到最大值。这项研究表明，血流运动频率可能是局部驱动的，而功率可能是由中枢介导的。微循环血流运动的紊乱可能是导致皮肤缺血和压疮的机制的一部分。已经开发出一种新方法来分析血流运动行为的差异，以便能够进行统计比较。
