Rossi M, Carpi A, Galetta F, Franzoni F, Santoro G
Department of Internal Medicine, Department of Reproduction and Ageing, University of Pisa, Via Roma, 67, Pisa, Italy.
Biomed Pharmacother. 2006 Sep;60(8):437-42. doi: 10.1016/j.biopha.2006.07.012. Epub 2006 Aug 14.
Skin blood flow oscillation, the so called flowmotion, is a consequence of the arteriolar diameter oscillations, i.e. vasomotion, and it is thought to play a critical role in favoring the optimal distribution of blood flow in the skin microvascular bed. Investigation of skin blood flowmotion, using spectral analysis of the skin laser Doppler flowmetry (LDF) signal, showed different flowmotion waves of endothelial, sympathetic or myogenic mediated vasomotion origin. Using this method in peripheral arterial obstructive disease (PAOD) patients an impairment of all the three flowmotion waves was found at level of the diseased leg following ischemia in the II stage of the disease and basally in critical limb ischemia. In patients with essential arterial hypertension (EHT) forearm skin blood flowmotion showed a post-ischemic impairment of myogenic and sympathetic components in newly diagnosed patients, and of endothelial and sympathetic components in long standing patients. In diabetic patients there was a selective impairment of skin flowmotion wave mediated by sympathetic activity in basal conditions. Investigation of skin blood flowmotion in response to different vasoactive substances demonstrated an important role of nitric oxide (NO) in controlling the endothelial component of vasomotion and an insulin action on smooth muscle cells of skin microvessels. All these data suggest that the study of skin blood flowmotion can become a method to early and easily detect skin microvascular impairment in vascular diseases and to investigate the mechanisms of substances active on skin microvascular bed.
皮肤血流振荡，即所谓的血流运动，是小动脉直径振荡（即血管运动）的结果，并且被认为在促进皮肤微血管床中血流的最佳分布方面起着关键作用。利用皮肤激光多普勒血流仪（LDF）信号的频谱分析对皮肤血流运动进行研究，结果显示内皮、交感神经或肌源性介导的血管运动起源的不同血流运动波。在周围动脉闭塞性疾病（PAOD）患者中使用这种方法，发现在疾病的II期缺血后以及在严重肢体缺血的基础状态下，患病肢体水平的所有三种血流运动波均受损。在原发性动脉高血压（EHT）患者中，前臂皮肤血流运动在新诊断患者中显示出缺血后肌源性和交感神经成分的受损，而在长期患者中显示出内皮和交感神经成分的受损。在糖尿病患者中，基础状态下由交感神经活动介导的皮肤血流运动波存在选择性受损。对不同血管活性物质反应的皮肤血流运动研究表明，一氧化氮（NO）在控制血管运动的内皮成分方面起着重要作用，以及胰岛素对皮肤微血管平滑肌细胞的作用。所有这些数据表明，皮肤血流运动的研究可以成为一种早期且轻松检测血管疾病中皮肤微血管损伤以及研究作用于皮肤微血管床的物质机制的方法。
