Ishii K, Kitagaki H, Sakamoto S, Yamaji S, Kono M
Department of Radiology, Hyogo Institute for Aging Brain and Cognitive Disorders.
Nihon Igaku Hoshasen Gakkai Zasshi. 1995 Aug;55(9):646-50.
To evaluate the utility of measuring interuncal distance (IUD) as a reflection of the limbic system, we compared the IUD of 60 dementia patients with that of 10 normal controls. We also measured the width of the intracranial compartment (W1 and W2) to correct for differences in individual brain size, and calculated the ratio of IUD/W1 and IUD/W2. IUD could not separate patients with dementia from normal controls, but there were significant differences in IUD/W1 and IUD/W2 between patients with dementia and normal controls. IUD, IUD/W1 and IUD/W2 did not correlate with Mini-Mental Examination score or ADAS score in patients with dementia. We conclude that IUD measurement is not helpful in distinguishing patients with mild stage dementia from normal aged people or as a scale for dementia. However, we suggest that IUD/W1 and IUD/W2 can discriminate between cases of mild dementia and normal aged people.
为评估测量大脑脚间距离（IUD）作为边缘系统反映指标的效用，我们比较了60例痴呆患者与10例正常对照者的IUD。我们还测量了颅内腔室的宽度（W1和W2）以校正个体脑大小的差异，并计算了IUD/W1和IUD/W2的比值。IUD无法区分痴呆患者与正常对照者，但痴呆患者与正常对照者之间的IUD/W1和IUD/W2存在显著差异。IUD、IUD/W1和IUD/W2与痴呆患者的简易精神状态检查评分或阿尔茨海默病评定量表（ADAS）评分均无相关性。我们得出结论，IUD测量无助于区分轻度痴呆患者与正常老年人，也无助于作为痴呆的一个量表。然而，我们建议IUD/W1和IUD/W2可区分轻度痴呆病例与正常老年人。
