Early B, Escalona P R, Boyko O B, Doraiswamy P M, Axelson D A, Patterson L, McDonald W M, Krishnan K R
Department of Psychiatry, Duke University Medical Center, Durham, NC 27710.
AJNR Am J Neuroradiol. 1993 Jul-Aug;14(4):907-10.
To evaluate further the clinical utility of the interuncal distance (IUD) measured from axial MR scans as a reflection of hippocampal atrophy.
The IUD measured from the axial MR scans of 17 healthy control subjects was correlated with the volume of the amygdala hippocampal complex obtained from coronal MR images. The IUD was also measured on axial MR scans in 12 patients with possible or probable Alzheimer disease.
The correlation between the total amygdala hippocampal volume and the IUD was insignificant for control subjects (r = -0.38, P = .13). When analysis of covariance was performed with the IUD as the dependent variable and age and diagnosis as the independent variables, overall R2 was 0.25. Age (F = 5.02, df = 1, P = .034), but not diagnosis (F = 0.02, df = 2, P = .88), had a significant effect.
The IUD has no significant correlation with the amygdala hippocampal volume. The IUD appears to be a better measure of overall brain volume, which changes with age. In our patient population diagnosed with mild to moderate Alzheimer disease, the IUD measurement was not found to be useful in distinguishing their scans from those of the volunteers.
进一步评估通过轴向磁共振成像（MR）扫描测量的脑沟间距离（IUD）作为海马萎缩反映指标的临床实用性。
对17名健康对照者的轴向MR扫描测量的IUD与从冠状面MR图像获得的杏仁核海马复合体体积进行相关性分析。还对12例可能或疑似阿尔茨海默病患者进行了轴向MR扫描测量IUD。
对照者的杏仁核海马总体积与IUD之间的相关性不显著（r = -0.38，P = 0.13）。以IUD作为因变量，年龄和诊断作为自变量进行协方差分析时，总体R2为0.25。年龄（F = 5.02，自由度 = 1，P = 0.034）有显著影响，而诊断（F = 0.02，自由度 = 2，P = 0.88）无显著影响。
IUD与杏仁核海马体积无显著相关性。IUD似乎是衡量随年龄变化的全脑体积的更好指标。在我们诊断为轻度至中度阿尔茨海默病的患者群体中，未发现IUD测量有助于将他们的扫描图像与志愿者的扫描图像区分开来。
