大脑脚间池距离：衰老和阿尔茨海默病的标志物。
Interuncal distance: marker of aging and Alzheimer disease.
作者信息
Howieson J, Kaye J A, Holm L, Howieson D
机构信息
Department of Diagnostic Radiology, Oregon Health Sciences University, Portland 97201.
出版信息
AJNR Am J Neuroradiol. 1993 May-Jun;14(3):647-50.
PURPOSE
To evaluate the utility of a recently reported simple measure of brain atrophy on MR imaging, the interuncal distance (IUD).
METHODS
Measurements of the IUD were made over a 12-month interval in 10 patients with probable early Alzheimer disease and in a comparison group of age-matched healthy control subjects. The measurements were made in both the transaxial and coronal planes.
RESULTS
Significant group differences for the coronal measurement of IUD were found in both the absolute value of the measurement and the IUD corrected for head size. There was overlap in IUD between the disease and the control groups. These differences were not found for the transaxial IUD. Significant positive correlations of the IUD with Mini-Mental State Examination score and Clinical Dementia Rating Scale stage were observed. Over the age range tested, age was not significantly correlated with IUD in the sample.
CONCLUSIONS
The interuncal distance (IUD) is not a useful screening measurement for Alzheimer disease.
目的
评估磁共振成像（MR）上最近报道的一种简单脑萎缩测量指标——脑间距离（IUD）的效用。
方法
在12个月的时间间隔内，对10例可能患有早期阿尔茨海默病的患者以及年龄匹配的健康对照受试者组成的比较组进行IUD测量。测量在横断面和冠状面进行。
结果
在IUD的冠状面测量中，无论是测量的绝对值还是校正头围后的IUD，两组之间均存在显著差异。疾病组和对照组的IUD存在重叠。横断面IUD未发现这些差异。观察到IUD与简易精神状态检查表评分和临床痴呆评定量表阶段存在显著正相关。在测试的年龄范围内，样本中年龄与IUD无显著相关性。
结论
脑间距离（IUD）不是阿尔茨海默病的有效筛查指标。
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