Eriksson P M, Sandström K B, Rosenholm J B
Department of Physical Chemistry, Abo Akademi University, Turku, Finland.
Pharm Res. 1995 May;12(5):715-9. doi: 10.1023/a:1016263610165.
The distribution of oleic acid between Salbutamol base drug and the solvent in metered-dose inhalers (MDI's) has been investigated. The equilibrium surfactant concentration in the drug dispersions has been determined using a colorimetric method. The samples examined contained Salbutamol base drug particles and oleic acid dispersed in different propellant blends of freon 11 and 12. The maximum equilibrium concentration observed depended on the propellant blend used. The propellant blend and the distribution of the surfactant affected the dispersion stability. The effect of the surfactant is illustrated by the adsorption isotherm for oleic acid onto the Salbutamol particles. The results are correlated with zeta-potentials and particle size measurements made on similar systems in order to characterize the properties of surfactant stabilized MDI's.
已对油酸在定量吸入器（MDI）中沙丁胺醇碱药物与溶剂之间的分布进行了研究。已使用比色法测定了药物分散体中的平衡表面活性剂浓度。所检测的样品包含分散在氟利昂11和12的不同推进剂混合物中的沙丁胺醇碱药物颗粒和油酸。观察到的最大平衡浓度取决于所使用的推进剂混合物。推进剂混合物和表面活性剂的分布影响分散稳定性。油酸在沙丁胺醇颗粒上的吸附等温线说明了表面活性剂的作用。为了表征表面活性剂稳定的MDI的性质，将结果与在类似系统上进行的ζ电位和粒度测量相关联。
