• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Fine specificity of the antibody response to myelin basic protein in the central nervous system in multiple sclerosis: the minimal B-cell epitope and a model of its features.多发性硬化症中枢神经系统中针对髓鞘碱性蛋白的抗体反应的精细特异性：最小B细胞表位及其特征模型。
Proc Natl Acad Sci U S A. 1995 Nov 21;92(24):11061-5. doi: 10.1073/pnas.92.24.11061.
2
T cell response to myelin basic protein in the context of the multiple sclerosis-associated HLA-DR15 haplotype: peptide binding, immunodominance and effector functions of T cells.在与多发性硬化症相关的HLA - DR15单倍型背景下T细胞对髓鞘碱性蛋白的反应：T细胞的肽结合、免疫显性及效应功能
J Neuroimmunol. 1997 Aug;77(2):195-203. doi: 10.1016/s0165-5728(97)00075-1.
3
Recognition of the immunodominant myelin basic protein peptide by autoantibodies and HLA-DR2-restricted T cell clones from multiple sclerosis patients. Identity of key contact residues in the B-cell and T-cell epitopes.来自多发性硬化症患者的自身抗体和HLA - DR2限制性T细胞克隆对免疫显性髓鞘碱性蛋白肽的识别。B细胞和T细胞表位中关键接触残基的一致性。
J Clin Invest. 1997 Sep 1;100(5):1114-22. doi: 10.1172/JCI119622.
4
The effect of intrathecal MBP synthetic peptides containing epitope P85 VVHFFKNIVTP96 on free anti-MBP levels in acute relapsing multiple sclerosis.含有表位P85 VVHFFKNIVTP96的鞘内注射髓鞘碱性蛋白（MBP）合成肽对急性复发型多发性硬化症中游离抗MBP水平的影响
J Neurol Sci. 1997 May 1;148(1):67-78. doi: 10.1016/s0022-510x(96)05331-2.
5
Myelin basic protein-specific T lymphocyte repertoire in multiple sclerosis. Complexity of the response and dominance of nested epitopes due to recruitment of multiple T cell clones.多发性硬化症中髓鞘碱性蛋白特异性T淋巴细胞库。由于多个T细胞克隆的募集导致反应的复杂性和嵌套表位的优势。
J Clin Invest. 1993 Dec;92(6):2633-43. doi: 10.1172/JCI116879.
6
Kinetic profiles of cerebrospinal fluid anti-MBP in response to intravenous MBP synthetic peptide DENP(85)VVHFFKNIVTP(96)RT in multiple sclerosis patients.多发性硬化症患者静脉注射髓鞘碱性蛋白合成肽DENP(85)VVHFFKNIVTP(96)RT后脑脊液抗髓鞘碱性蛋白的动力学曲线。
Mult Scler. 2000 Oct;6(5):300-11. doi: 10.1177/135245850000600502.
7
Myelin autoreactivity in multiple sclerosis: recognition of myelin basic protein in the context of HLA-DR2 products by T lymphocytes of multiple-sclerosis patients and healthy donors.多发性硬化症中的髓鞘自身反应性：多发性硬化症患者和健康供体的T淋巴细胞在HLA - DR2产物背景下对髓鞘碱性蛋白的识别。
Proc Natl Acad Sci U S A. 1990 Oct;87(20):7968-72. doi: 10.1073/pnas.87.20.7968.
8
Immunodominance of a low-affinity major histocompatibility complex-binding myelin basic protein epitope (residues 111-129) in HLA-DR4 (B1*0401) subjects is associated with a restricted T cell receptor repertoire.在HLA - DR4（B1*0401）受试者中，低亲和力的主要组织相容性复合体结合髓鞘碱性蛋白表位（第111 - 129位氨基酸残基）的免疫显性与受限的T细胞受体库相关。
J Clin Invest. 1997 Jul 15;100(2):339-49. doi: 10.1172/JCI119539.
9
Myelin basic protein intramolecular spreading without disease progression in a patient with multiple sclerosis.多发性硬化症患者中髓鞘碱性蛋白分子内扩散但无疾病进展
J Neuroimmunol. 2000 Oct 2;110(1-2):240-3. doi: 10.1016/s0165-5728(00)00342-8.
10
Administration of myelin basic protein synthetic peptides to multiple sclerosis patients.向多发性硬化症患者施用髓鞘碱性蛋白合成肽。
J Neurol Sci. 1995 Nov;133(1-2):85-94. doi: 10.1016/0022-510x(95)00187-7.

引用本文的文献

1
The intrinsically disordered protein glue of the myelin major dense line: Linking AlphaFold2 predictions to experimental data.髓鞘主要致密线的内在无序蛋白胶：将AlphaFold2预测与实验数据联系起来。
Biochem Biophys Rep. 2023 Apr 26;34:101474. doi: 10.1016/j.bbrep.2023.101474. eCollection 2023 Jul.
2
Role of Helical Structure in MBP Immunodominant Peptides for Efficient IgM Antibody Recognition in Multiple Sclerosis.螺旋结构在髓鞘碱性蛋白免疫显性肽在多发性硬化症中高效IgM抗体识别中的作用
Front Chem. 2022 Jun 20;10:885180. doi: 10.3389/fchem.2022.885180. eCollection 2022.
3
Flexible Players within the Sheaths: The Intrinsically Disordered Proteins of Myelin in Health and Disease.鞘内的柔性分子：髓鞘中固有无序蛋白在健康和疾病中的作用。
Cells. 2020 Feb 18;9(2):470. doi: 10.3390/cells9020470.
4
Extracellular Vesicles in Epstein-Barr Virus Pathogenesis.爱泼斯坦-巴尔病毒致病机制中的细胞外囊泡
Curr Clin Microbiol Rep. 2019 Sep;6(3):121-131. doi: 10.1007/s40588-019-00123-6. Epub 2019 Jul 3.
5
An Overview of the Intrinsic Role of Citrullination in Autoimmune Disorders.瓜氨酸化在自身免疫性疾病中的固有作用概述。
J Immunol Res. 2019 Nov 25;2019:7592851. doi: 10.1155/2019/7592851. eCollection 2019.
6
Hinge-deleted IgG4 blocker therapy for acetylcholine receptor myasthenia gravis in rhesus monkeys.铰链缺失 IgG4 阻断剂治疗恒河猴乙酰胆碱受体肌无力。
Sci Rep. 2017 Apr 20;7(1):992. doi: 10.1038/s41598-017-01019-5.
7
Myelin Basic Protein and a Multiple Sclerosis-related MBP-peptide Bind to Oligonucleotides.髓鞘碱性蛋白和与多发性硬化症相关的 MBP 肽与寡核苷酸结合。
Mol Ther Nucleic Acids. 2014 Sep 9;3(9):e192. doi: 10.1038/mtna.2014.43.
8
Autoantibodies to Non-myelin Antigens as Contributors to the Pathogenesis of Multiple Sclerosis.针对非髓鞘抗原的自身抗体在多发性硬化症发病机制中的作用
J Clin Cell Immunol. 2013 Jun 30;4. doi: 10.4172/2155-9899.1000148.
9
Adduction of cholesterol 5,6-secosterol aldehyde to membrane-bound myelin basic protein exposes an immunodominant epitope.胆固醇 5,6-甾体醛向膜结合髓鞘碱性蛋白的内收暴露了一个免疫优势表位。
Biochemistry. 2011 Mar 29;50(12):2092-100. doi: 10.1021/bi200109q. Epub 2011 Feb 28.
10
Systems biology approaches for the study of multiple sclerosis.用于多发性硬化症研究的系统生物学方法。
J Cell Mol Med. 2008 Aug;12(4):1087-93. doi: 10.1111/j.1582-4934.2008.00375.x. Epub 2008 May 26.

本文引用的文献

1
Major T-cell responses in multiple sclerosis.多发性硬化症中的主要T细胞反应。
Mol Med Today. 1995 May;1(2):79-83. doi: 10.1016/s1357-4310(95)92366-7.
2
The epigenetics of multiple sclerosis: clues to etiology and a rationale for immune therapy.多发性硬化症的表观遗传学：病因线索及免疫治疗的理论依据
Annu Rev Neurosci. 1994;17:247-65. doi: 10.1146/annurev.ne.17.030194.001335.
3
Oligodendrocyte-specific expression and autoantigenicity of transaldolase in multiple sclerosis.转醛醇酶在多发性硬化症中的少突胶质细胞特异性表达及自身抗原性
J Exp Med. 1994 Nov 1;180(5):1649-63. doi: 10.1084/jem.180.5.1649.
4
Escape from "horror autotoxicus": pathogenesis and treatment of autoimmune disease.摆脱“自身中毒恐怖症”：自身免疫性疾病的发病机制与治疗
Cell. 1995 Jan 13;80(1):7-10. doi: 10.1016/0092-8674(95)90443-3.
5
Autoantibodies to myelin basic protein within multiple sclerosis central nervous system tissue.多发性硬化症中枢神经系统组织内针对髓鞘碱性蛋白的自身抗体。
J Neurol Sci. 1993 Apr;115(2):169-76. doi: 10.1016/0022-510x(93)90221-j.
6
Increased synthetic peptide specificity of tissue-CSF bound anti-MBP in multiple sclerosis.多发性硬化症中组织-脑脊液结合抗髓鞘碱性蛋白的合成肽特异性增加。
J Neuroimmunol. 1993 Mar;43(1-2):87-96. doi: 10.1016/0165-5728(93)90078-d.
7
Selection for T-cell receptor V beta-D beta-J beta gene rearrangements with specificity for a myelin basic protein peptide in brain lesions of multiple sclerosis.在多发性硬化症脑损伤中选择对髓鞘碱性蛋白肽具有特异性的T细胞受体Vβ-Dβ-Jβ基因重排。
Nature. 1993 Mar 4;362(6415):68-70. doi: 10.1038/362068a0.
8
Binding of myelin basic protein peptides to human histocompatibility leukocyte antigen class II molecules and their recognition by T cells from multiple sclerosis patients.髓鞘碱性蛋白肽与人组织相容性白细胞抗原II类分子的结合及其被多发性硬化症患者T细胞的识别。
J Clin Invest. 1993 Feb;91(2):616-28. doi: 10.1172/JCI116242.
9
Molecular mimicry in T cell-mediated autoimmunity: viral peptides activate human T cell clones specific for myelin basic protein.T细胞介导的自身免疫中的分子模拟：病毒肽激活针对髓鞘碱性蛋白的人T细胞克隆。
Cell. 1995 Mar 10;80(5):695-705. doi: 10.1016/0092-8674(95)90348-8.
10
Reversal of experimental autoimmune encephalomyelitis by a soluble peptide variant of a myelin basic protein epitope: T cell receptor antagonism and reduction of interferon gamma and tumor necrosis factor alpha production.髓鞘碱性蛋白表位的可溶性肽变体对实验性自身免疫性脑脊髓炎的逆转作用：T细胞受体拮抗及γ干扰素和肿瘤坏死因子α生成的减少
J Exp Med. 1994 Dec 1;180(6):2227-37. doi: 10.1084/jem.180.6.2227.

多发性硬化症中枢神经系统中针对髓鞘碱性蛋白的抗体反应的精细特异性：最小B细胞表位及其特征模型。

Fine specificity of the antibody response to myelin basic protein in the central nervous system in multiple sclerosis: the minimal B-cell epitope and a model of its features.

作者信息

Warren K G, Catz I, Steinman L

机构信息

Multiple Sclerosis Patient Care and Research Clinic, University of Alberta, Edmonton, Canada.

出版信息

Proc Natl Acad Sci U S A. 1995 Nov 21;92(24):11061-5. doi: 10.1073/pnas.92.24.11061.

DOI:10.1073/pnas.92.24.11061
PMID:7479937
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC40571/
Abstract

T cells, B cells, and antibody are found in the white matter of the central nervous system in multiple sclerosis. The epitope center for the antibody response to human myelin basic protein (MBP) fits precisely the minimal epitope Pro85-Val-Val-His-Phe-Phe-Lys-Asn-Ile-Val-Thr-Pro96 for that reported for HLA DR2b (DRB1*1501)-restricted T cells that recognize MBP [Wucherpfenning, K.W., Sette, A., Southwood, S., Oseroff, C., Matsui, M., Strominger, J. & Hafler, D. (1994) J. Exp. Med. 179, 279-290], and overlaps with the reported DR2a-restricted epitope for T cells reactive to MBP [Martin, R., Howell, M. D., Jaraquemada, D., Furlage, M., Richert, J., Brostoff, S., Long, E. O., McFarlin, D. E. & McFarland, H. F. (1991) J. Exp. Med. 173, 19-24]. We describe a molecular model of this epitope.

摘要

在多发性硬化症中，T细胞、B细胞和抗体存在于中枢神经系统的白质中。针对人髓鞘碱性蛋白（MBP）的抗体反应的表位中心与针对识别MBP的HLA DR2b（DRB1*1501）限制性T细胞所报道的最小表位Pro85-Val-Val-His-Phe-Phe-Lys-Asn-Ile-Val-Thr-Pro96精确匹配[武克芬宁，K.W.，塞特，A.，索思伍德，S.，奥塞罗夫，C.，松井，M.，斯特罗明格，J.和哈弗勒，D.（1994年）《实验医学杂志》179，279 - 290]，并且与所报道的对MBP有反应的DR2a限制性T细胞表位重叠[马丁，R.，豪厄尔，M.D.，雅拉凯马达，D.，弗拉格，M.，里歇特，J.，布罗斯托夫，S.，朗，E.O.，麦克法林，D.E.和麦克法兰，H.F.（1991年）《实验医学杂志》173，19 - 24]。我们描述了这个表位的分子模型。