多发性硬化症中枢神经系统中针对髓鞘碱性蛋白的抗体反应的精细特异性：最小B细胞表位及其特征模型。
Fine specificity of the antibody response to myelin basic protein in the central nervous system in multiple sclerosis: the minimal B-cell epitope and a model of its features.
作者信息
Warren K G, Catz I, Steinman L
机构信息
Multiple Sclerosis Patient Care and Research Clinic, University of Alberta, Edmonton, Canada.
出版信息
Proc Natl Acad Sci U S A. 1995 Nov 21;92(24):11061-5. doi: 10.1073/pnas.92.24.11061.
Abstract
T cells, B cells, and antibody are found in the white matter of the central nervous system in multiple sclerosis. The epitope center for the antibody response to human myelin basic protein (MBP) fits precisely the minimal epitope Pro85-Val-Val-His-Phe-Phe-Lys-Asn-Ile-Val-Thr-Pro96 for that reported for HLA DR2b (DRB1*1501)-restricted T cells that recognize MBP [Wucherpfenning, K.W., Sette, A., Southwood, S., Oseroff, C., Matsui, M., Strominger, J. & Hafler, D. (1994) J. Exp. Med. 179, 279-290], and overlaps with the reported DR2a-restricted epitope for T cells reactive to MBP [Martin, R., Howell, M. D., Jaraquemada, D., Furlage, M., Richert, J., Brostoff, S., Long, E. O., McFarlin, D. E. & McFarland, H. F. (1991) J. Exp. Med. 173, 19-24]. We describe a molecular model of this epitope.
摘要
在多发性硬化症中，T细胞、B细胞和抗体存在于中枢神经系统的白质中。针对人髓鞘碱性蛋白（MBP）的抗体反应的表位中心与针对识别MBP的HLA DR2b（DRB1*1501）限制性T细胞所报道的最小表位Pro85-Val-Val-His-Phe-Phe-Lys-Asn-Ile-Val-Thr-Pro96精确匹配[武克芬宁，K.W.，塞特，A.，索思伍德，S.，奥塞罗夫，C.，松井，M.，斯特罗明格，J.和哈弗勒，D.（1994年）《实验医学杂志》179，279 - 290]，并且与所报道的对MBP有反应的DR2a限制性T细胞表位重叠[马丁，R.，豪厄尔，M.D.，雅拉凯马达，D.，弗拉格，M.，里歇特，J.，布罗斯托夫，S.，朗，E.O.，麦克法林，D.E.和麦克法兰，H.F.（1991年）《实验医学杂志》173，19 - 24]。我们描述了这个表位的分子模型。
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