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植物化合物作为潜在抗病毒剂的作用:概述。

Role of phytocompounds as the potential anti-viral agent: an overview.

机构信息

Department of Medical Oncology, IMS & Sum Hospital, Siksha 'O' Anusandhan Deemed to Be University, Bhubaneswar, 751003, Odisha, India.

Central Research Laboratory, IMS & Sum Hospital, Siksha 'O' Anusandhan Deemed to Be University, Bhubaneswar, 751003, Odisha, India.

出版信息

Naunyn Schmiedebergs Arch Pharmacol. 2023 Oct;396(10):2311-2329. doi: 10.1007/s00210-023-02517-2. Epub 2023 May 9.

Abstract

Viral diseases are the most notorious infective agent(s) causing morbidity and mortality in every nook and corner for ages; viruses are active in host cells, and specific anti-virus medicines' developments remain uncanny. In this century of the biological era, human viruses act predominantly as versatile spreaders. The infection of the present COVID-19 virus is up in the air; blithely, the integument of medicinal chemistry approaches, particularly bioactive derived phytocompounds could be helpful to control those human viruses, recognized in the last 100 years. Indeed, natural products are being used for various therapeutic purposes. The major bioactive phytocompounds are chemically containing coumarin, thiosulfonate, steroid, polysaccharide, tannin, lignin, proanthocyanidin, terpene, quinone, saponin, flavonoid, alkaloid, and polyphenol, that are documented for inhibitory action against several viral infections. Mostly, about 20-30% of plants from tropical or temperate regions are known to have some antiviral activity. This comprehensive analysis of bioactive-derived phytocompounds would represent a significant impact and might be helpful for antiviral research and the current state of viral treatments.

摘要

病毒疾病是最臭名昭著的感染性病原体,它们在各个角落造成发病率和死亡率已有很长时间了;病毒在宿主细胞中活跃,而特定的抗病毒药物的发展仍然是神秘莫测的。在这个生物学时代的世纪里,人类病毒主要充当多功能的传播者。目前 COVID-19 病毒的感染情况尚不明朗;不过,药物化学的方法,特别是生物活性衍生的植物化合物,可能有助于控制过去 100 年来发现的那些人类病毒。事实上,天然产物正在被用于各种治疗目的。主要的生物活性植物化合物在化学上含有香豆素、硫代硫酸盐、甾体、多糖、单宁、木质素、原花青素、萜烯、醌、皂苷、类黄酮、生物碱和多酚,这些化合物被证明对多种病毒感染具有抑制作用。大约有 20-30%的热带或温带地区的植物被认为具有一些抗病毒活性。对生物活性衍生植物化合物的这种全面分析将产生重大影响,并可能有助于抗病毒研究和目前的病毒治疗状况。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/38a1/10169142/5a829daf1284/210_2023_2517_Fig1_HTML.jpg

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