Balakrishnan Rengasamy, Cho Duk-Yeon, Su-Kim In, Choi Dong-Kug
Department of Applied Life Sciences and Integrated Bioscience, Graduate School, Konkuk University, Chungju 27478, Korea.
Antioxidants (Basel). 2020 Oct 8;9(10):962. doi: 10.3390/antiox9100962.
The genus is a kind of flowering plant in the family of Araliaceae that encompasses approximately 91 to 95 species. Several species are used as traditional medicinal plants, extensively used Korea and South America and other parts of the world. Almost every part of the plant, including the leaves, bark, roots, and stems, can be used as traditional medicine for the prevention and management of a broad spectrum of health disorders. This paper sought to summarizes the ethnopharmacological benefits, biological activities, and phytochemical investigations of plants from the genus and perhaps to subsequently elucidate potential new perspectives for future pharmacological research to consider. Modern scientific literature suggests that plants of the genus, together with active compounds isolated from it, possess a wide range of therapeutic and pharmacological applications, including antifungal, anti-complement, antioxidant, antibacterial, insect antifeedant, cytotoxic, anti-inflammatory, neuroprotective, anti-diabetic, anti-cancer, and anti-hypouricemic properties. The botanical descriptions of approximately six to 10 species are provided by different scientific web sources. However, only six species, namely, , , and , were included in the present investigation to undergo phytochemical evaluation, due to the unavailability of data for the remaining species. Among these plant species, a high concentration of variable bioactive ingredients was identified. In particular, is a traditional medicinal plant used for the multiple treatment purposes and management of several human diseases or health conditions. Previous experimental evidence supports that the species could be used to treat various inflammatory disorders, diarrhea, diabetes, cancer, and some microbial infections. It has recently been reported, by our group and other researchers, that possesses a neuroprotective and memory-enhancing agent. A total of 259 compounds have been identified among six species, with 78 sourced from five of these species reported to be bioactive. However, there is no up-to-date information concerning the , its different biological properties, or its prospective benefits in the enhancement of human health. In the present study, we set out to conduct a comprehensive analysis of the botany, traditional medicinal history, and medicinal resources of species of the genus. In addition, we explore several phytochemical constituents identified in different species of the genus and their biological properties. Finally, we offer comprehensive analysis findings of the phytochemistry, medicinal uses, pharmacological actions, and a toxicity and safety evaluation of the species and its main bioactive ingredients for future consideration.
该属是五加科的一种开花植物，包含约91至95个物种。有几个物种被用作传统药用植物，在韩国、南美洲和世界其他地区广泛使用。该植物几乎每个部分，包括叶子、树皮、根和茎，都可作为传统药物用于预防和治疗多种健康疾病。本文旨在总结该属植物的民族药理学益处、生物活性和植物化学研究，或许随后阐明未来药理学研究可考虑的潜在新视角。现代科学文献表明，该属植物及其从中分离出的活性化合物具有广泛的治疗和药理应用，包括抗真菌、抗补体、抗氧化、抗菌、昆虫拒食、细胞毒性、抗炎、神经保护、抗糖尿病、抗癌和抗高尿酸血症特性。不同科学网站提供了约6至10个物种的植物学描述。然而，由于其余物种数据不可用，本研究仅纳入了六个物种，即[具体物种名称1]、[具体物种名称2]、[具体物种名称3]、[具体物种名称4]、[具体物种名称5]和[具体物种名称6]进行植物化学评估。在这些植物物种中，鉴定出了高浓度的多种生物活性成分。特别是，[具体物种名称]是一种用于多种治疗目的和治疗多种人类疾病或健康状况的传统药用植物。先前的实验证据支持该物种可用于治疗各种炎症性疾病、腹泻、糖尿病、癌症和一些微生物感染。最近，我们团队和其他研究人员报道，[具体物种名称]具有神经保护和增强记忆的作用。在六个物种中共鉴定出259种化合物，其中来自其中五个物种的78种据报道具有生物活性。然而，关于[具体物种名称]及其不同生物学特性或其在促进人类健康方面的潜在益处，尚无最新信息。在本研究中，我们着手对该属物种的植物学、传统药用历史和药用资源进行全面分析。此外，我们探索了在该属不同物种中鉴定出的几种植物化学成分及其生物学特性。最后，我们提供了该物种及其主要生物活性成分的植物化学、药用用途、药理作用以及毒性和安全性评估的综合分析结果，以供未来参考。
