Schusdziarra V, Rouiller D, Arimura A, Unger R H
Endocrinology. 1978 Nov;103(5):1956-9. doi: 10.1210/endo-103-5-1956.
The effects of antisomatostatin serum upon the levels of growth hormone, glucagon-like immunoreactivity (GLI), glucagon, insulin and post-prandial triglyceride levels were examined in a group of 5 dogs before and after a fat-rich meal. Within 1 min after the injection of sheep antisomatostatin, plasma growth hormone and GLI levels increased significantly above baseline levels before the meal and remained elevated for 45 to 60 min after the meal, whereas the administration of nonimmune sheep serum to the same dogs did not cause significant changes in either hormone. Plasma insulin, glucagon and triglyceride levels after antisomatostatin serum were not significantly different from the controls. These findings suggest that endogenous somatostatin influences the secretion of growth hormone and GLI via a pathway readily accessible to intravenously injected antibodies, probably via the circulation, whereas any influence that somatostatin may have upon the secretion of insulin and glucagon must take place via a pathway inaccessible to intravenously administered antisomatostatin serum, i.e. within the islets themselves.
在一组5只狗身上，检测了富含脂肪餐前后抗生长抑素血清对生长激素、胰高血糖素样免疫活性（GLI）、胰高血糖素、胰岛素水平以及餐后甘油三酯水平的影响。注射羊抗生长抑素后1分钟内，血浆生长激素和GLI水平显著高于餐前基线水平，并在餐后45至60分钟内保持升高，而给相同的狗注射非免疫羊血清则未引起这两种激素的显著变化。抗生长抑素血清处理后的血浆胰岛素、胰高血糖素和甘油三酯水平与对照组无显著差异。这些发现表明，内源性生长抑素通过静脉注射抗体易于进入的途径，可能是通过循环，影响生长激素和GLI的分泌，而生长抑素对胰岛素和胰高血糖素分泌的任何影响必定是通过静脉注射抗生长抑素血清无法进入的途径发生的，即在胰岛本身内部。
