Alster T S
Georgetown University Medical Center, Washington, D.C., USA.
Plast Reconstr Surg. 1995 Dec;96(7):1660-4. doi: 10.1097/00006534-199512000-00020.
Traditional treatment modalities for café-au-lait spots include cryotherapy, dermabrasion, and excision with or without skin grafting. These treatments have shown varying degrees of success and, in some cases, have yielded significant side effects, such as permanent pigmentary alteration and scarring. The 510-nm pulsed dye laser has been shown to selectively destroy melanosomes that make up such epidermal pigmented lesions as café-au-lait spots without significant adverse sequelae. Thirty patients with 34 large café-au-lait birthmarks received 510-nm pulsed dye laser treatments at 6- to 8-week intervals with energy densities ranging from 2.0 to 4.0 J/cm2. An average of 8.4 laser treatments were necessary to achieve complete elimination of the café-au-lait marks under study. No lesional recurrences have been observed 1 year following termination of treatment.
咖啡斑的传统治疗方式包括冷冻疗法、磨皮术以及切除（伴或不伴植皮）。这些治疗已显示出不同程度的成功，但在某些情况下，会产生显著的副作用，如永久性色素改变和瘢痕形成。已证明510纳米脉冲染料激光可选择性地破坏构成咖啡斑等表皮色素性病变的黑素小体，且无明显不良后遗症。30例有34处大型咖啡斑胎记的患者接受了510纳米脉冲染料激光治疗，间隔6至8周，能量密度范围为2.0至4.0 J/cm²。平均需要8.4次激光治疗才能完全消除所研究的咖啡斑。治疗结束后1年未观察到病灶复发。
