Bluemke D A, Petri M, Zerhouni E A
Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins Hospital, Baltimore, MD 21287, USA.
Radiology. 1995 Nov;197(2):433-8. doi: 10.1148/radiology.197.2.7480688.
To measure fat content and relative marrow perfusion of the femoral head in patients at risk for avascular necrosis.
Thirteen patients with systemic lupus erythematosus (SLE) without avascular necrosis and with long-term corticosteroid treatment and 12 healthy subjects were evaluated. Hip perfusion was assessed with gadolinium-enhanced T1-weighted magnetic resonance (MR) imaging. Marrow composition in the femoral head and neck was measured with hydrogen-1 MR spectroscopy.
Percentage fat content in the femoral head was similar between the two groups (SLE patients, 77% +/- 5 [standard deviation]; healthy subjects, 78% +/- 6; P = .74). Rate of enhancement of the femoral head was significantly higher in the SLE than the healthy group (11%/min +/- 6 vs 6.9%/min +/- 3, respectively; P = .05), was inversely related to fat content in healthy subjects (r = -.74, P = .02), and was more variable in the SLE group (r = -.53, P = .11).
Perfusion of the femoral head is inversely related to marrow fat content in healthy and is higher in SLE patients without hip avascular necrosis.
测量有股骨头缺血性坏死风险患者的股骨头脂肪含量及相对骨髓灌注情况。
对13例无股骨头缺血性坏死且长期接受皮质类固醇治疗的系统性红斑狼疮（SLE）患者和12名健康受试者进行评估。采用钆增强T1加权磁共振（MR）成像评估髋关节灌注情况。用氢-1 MR波谱测量股骨头和颈部的骨髓成分。
两组之间股骨头的脂肪含量百分比相似（SLE患者为77%±5[标准差]；健康受试者为78%±6；P = 0.74）。SLE组股骨头的强化率显著高于健康组（分别为11%/分钟±6和6.9%/分钟±3；P = 0.05），在健康受试者中强化率与脂肪含量呈负相关（r = -0.74，P = 0.02），且在SLE组中变化更大（r = -0.53，P = 0.11）。
在健康人群中，股骨头灌注与骨髓脂肪含量呈负相关，且在无髋关节缺血性坏死的SLE患者中更高。
