Cova M, Kang Y S, Tsukamoto H, Jones L C, McVeigh E, Neff B L, Herold C J, Scott W W, Hungerford D S, Zerhouni E A
Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205.
Radiology. 1991 May;179(2):535-9. doi: 10.1148/radiology.179.2.2014306.
The authors studied, in a dog model, the feasibility of using gadolinium-enhanced dynamic magnetic resonance (MR) imaging to noninvasively monitor bone marrow perfusion of the proximal femur. With a gradient-recalled acquisition, sequential images of 10 hips in five healthy dogs were obtained for 14 minutes after an intravenous bolus injection of 0.2 mmol of gadopentetate dimeglumine per kilogram. The study was repeated after unilateral arterial embolization of major femoral vessels. Radiolabeled microspheres were injected before and after vessel occlusion. After unilateral embolization, statistically significant differences in enhancement were observed between embolized and control sides (eg, 31% vs 83% average peak enhancement in the femoral neck). There was a high correlation (r = .81 [average]) between the MR data and the microsphere blood flow measurements. The postembolization data indicate that contrast-enhanced fast MR imaging may allow early detection of abnormal bone marrow flow. This technique may be valuable in evaluating patients at risk for avascular necrosis of the femoral head, especially in posttraumatic cases.
作者在犬模型中研究了使用钆增强动态磁共振（MR）成像无创监测股骨近端骨髓灌注的可行性。采用梯度回波采集序列，在五只健康犬静脉注射每千克0.2 mmol钆喷酸葡胺大剂量团注后14分钟内，获取了10个髋关节的连续图像。在对主要股血管进行单侧动脉栓塞后重复该研究。在血管闭塞前后注射放射性标记微球。单侧栓塞后，栓塞侧与对照侧在强化方面观察到统计学上的显著差异（例如，股骨颈平均峰值强化分别为31%和83%）。MR数据与微球血流测量之间存在高度相关性（平均r = 0.81）。栓塞后的数据表明，对比增强快速MR成像可能有助于早期检测骨髓血流异常。该技术在评估有股骨头缺血性坏死风险的患者时可能具有重要价值，尤其是在创伤后病例中。
