Kayhan Arda, Yang Cheng, Soylu Fatma Nur, Lakadamyalı Hatice, Sethi Ila, Karczmar Gregory, Stadler Walter, Oto Aytekin
Arda Kayhan, Fatma Nur Soylu, Hatice Lakadamyalı, Ila Sethi, Gregory Karczmar, Aytekin Oto, Department of Radiology, University of Chicago, Chicago, IL 60637, United States.
World J Radiol. 2011 Oct 28;3(10):241-5. doi: 10.4329/wjr.v3.i10.241.
To evaluate the dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) findings of bone metastasis in prostate cancer patients.
Sixteen men with a diagnosis of metastatic prostate cancer to bones were examined with DCE-MRI at 1.5 Tesla. The mean contrast agent concentration vs time curves for bone metastasis and normal bone were calculated and K(trans) and ve values were estimated and compared.
An early significant enhancement (wash-out: n = 6, plateau: n = 8 and persistent: n = 2) was detected in all bone metastases (n = 16). Bone metastasis from prostate cancer showed significant enhancement and high K(trans) and ve values compared to normal bone which does not enhance in the elderly population. The mean K(trans) was 0.101/min and 0.0051/min (P < 0.001), the mean ve was 0.141 and 0.0038 (P < 0.001), for bone metastases and normal bone, respectively.
DCE-MRI and its quantitative perfusion parameters may have a role in improving the detection of skeletal metastasis in prostate cancer patients.
评估前列腺癌患者骨转移的动态对比增强磁共振成像（DCE-MRI）表现。
对16例诊断为前列腺癌骨转移的男性患者进行1.5特斯拉的DCE-MRI检查。计算骨转移灶和正常骨的平均对比剂浓度-时间曲线，并估算和比较K(trans)及ve值。
在所有16处骨转移灶中均检测到早期显著强化（廓清型：6处，平台型：8处，持续型：2处）。与老年人群中不强化的正常骨相比，前列腺癌骨转移灶表现出显著强化以及较高的K(trans)和ve值。骨转移灶和正常骨的平均K(trans)分别为0.101/min和0.0051/min（P < 0.001），平均ve分别为0.141和0.0038（P < 0.001）。
DCE-MRI及其定量灌注参数可能有助于提高前列腺癌患者骨转移的检测率。
