Hallagan J B, Hall R L
Regul Toxicol Pharmacol. 1995 Jun;21(3):422-30. doi: 10.1006/rtph.1995.1057.
The generally recognized as safe (GRAS) assessment program of the Flavor and Extract Manufacturers Association (FEMA) of the United States was initiated in 1959 to provide for the assessment of flavor ingredients as GRAS under the Food Additives Amendment to the U.S. Federal Food, Drug, and Cosmetic Act. FEMA sponsored the formation of an independent panel of experts to perform GRAS assessments and to provide their conclusions to the U.S. Food and Drug Administration, the food and flavor industries, and the public. The program was designed to account for the legal, regulatory, and scientific issues associated with GRAS assessments and has continued to incorporate changes in the law and in science. This review describes the legal and scientific foundation of the FEMA program.
美国香料与提取物制造商协会（FEMA）的一般认为安全（GRAS）评估计划始于1959年，旨在根据美国联邦食品、药品和化妆品法案的食品添加剂修正案，对香料成分进行GRAS评估。FEMA赞助成立了一个独立的专家小组，以进行GRAS评估，并将他们的结论提供给美国食品药品监督管理局、食品和香料行业以及公众。该计划旨在考虑与GRAS评估相关的法律、监管和科学问题，并持续纳入法律和科学方面的变化。本综述描述了FEMA计划的法律和科学基础。
