Hallagan John B, Hall Richard L
The Flavor and Extract Manufacturers Association, 1620 I Street, NW, Suite 925, Washington, DC 20006, United States.
Food Chem Toxicol. 2009 Feb;47(2):267-78. doi: 10.1016/j.fct.2008.11.011. Epub 2008 Nov 17.
In 1995 we published a review describing the scientific and legal bases for the GRAS assessment program for flavor ingredients sponsored by the Flavor and Extract Manufacturers Association of the United States (FEMA) [Hallagan, J.B., Hall, R.L., 1995. FEMA GRAS - A GRAS assessment program for flavor ingredients. Regulatory Toxicology and Pharmacology 21, 422]. This review provides new information related to flavor safety assessment and regulation and is intended to complement our previous report. The FEMA GRAS assessment program is the most extensive and longest running industry-sponsored GRAS program and has established a sound record of scientific rigor and transparency. In this review, in addition to providing general information on the topics of flavor safety assessment and regulation, we explore the effects of recent developments on the four pillars of the FEMA GRAS assessment program: (1) general recognition; (2) among experts qualified by scientific training and experience to evaluate safety; (3) through scientific procedures; (4) under the conditions of intended use in food. We conclude that developments since our last review in 1995 have further strengthened the FEMA GRAS assessment program allowing it to maintain its global leadership role in the safety assessment of flavor ingredients.
1995年，我们发表了一篇综述，描述了由美国香料和提取物制造商协会（FEMA）发起的香料成分GRAS评估计划的科学和法律依据[哈勒根，J.B.，霍尔，R.L.，1995年。FEMA GRAS——香料成分的GRAS评估计划。《监管毒理学与药理学》21，422]。本综述提供了与香料安全评估和监管相关的新信息，旨在补充我们之前的报告。FEMA GRAS评估计划是最广泛且运行时间最长的行业赞助的GRAS计划，并且在科学严谨性和透明度方面建立了良好的记录。在本综述中，除了提供关于香料安全评估和监管主题的一般信息外，我们还探讨了近期发展对FEMA GRAS评估计划四大支柱的影响：（1）普遍认可；（2）在具备科学培训和经验以评估安全性的专家之间；（3）通过科学程序；（4）在食品预期使用条件下。我们得出结论，自1995年我们上次综述以来的发展进一步加强了FEMA GRAS评估计划，使其能够在香料成分安全评估中保持其全球领先地位。
