Coelho P M, Pereira L H, de Mello R T
Departamentos de Parasitologia, Faculdade de Farmácia, Universidade Federal de Minas Gerais, Belo Horizonte.
Rev Soc Bras Med Trop. 1995 Jul-Sep;28(3):179-83. doi: 10.1590/s0037-86821995000300003.
In this study, four compounds were utilized at the dose of 12.5 mg/kg body weight, p.o., to treat Cebus monkeys experimentally infected with about 200 cercariae of Schistosoma mansoni (SJ strain), via transcutaneous route. The oograms performed with rectal snips, as well as stool examinations carried out periodically, showed no viable eggs of the parasite, from day 29 to 226 post-treatment. The perfusion undertaken after killing the animals showed absence of worms in the treated monkeys, whereas 83 worms were recovered from the control, thus corroborating the results obtained by means of oograms and coproscopy. These results confirm the efficacy of 9-acridanone-hydrazones previously tested against the LE strain of S. mansoni. The low curative dose and apparent absence of toxicity render these drugs an important therapeutic reserve, taking into consideration the reports on the resistance of S. mansoni to the modern drugs oxamniquine and praziquantel.
在本研究中，以12.5毫克/千克体重的剂量经口服给予四种化合物，用于治疗经皮感染约200只曼氏血吸虫（SJ株）尾蚴的卷尾猴。用直肠剪进行的虫卵计数图检查以及定期进行的粪便检查显示，在治疗后第29天至226天未发现寄生虫活卵。处死动物后进行的灌注显示，治疗组猴子体内没有虫体，而对照组则检出83条虫体，从而证实了通过虫卵计数图检查和粪便检查获得的结果。这些结果证实了先前测试的9-吖啶酮腙对曼氏血吸虫LE株的疗效。考虑到有关曼氏血吸虫对现代药物奥沙尼喹和吡喹酮耐药性的报道，低治疗剂量和明显无毒性使这些药物成为重要治疗储备。
