Pereira L H, Coelho P M, Costa J O, de Mello R T
Departamento de Parasitologia, ICB, Universidade Federal de Minas Gerais, Belo Horizonte, Brasil.
Mem Inst Oswaldo Cruz. 1995 May-Jun;90(3):425-8. doi: 10.1590/s0074-02761995000300021.
The compound Ro-15.5458/000, derivative in the class of 9-acridanone-hydrazones, was found to be effective against Schistosoma mansoni in mice, killing almost all the skin schistosomules (24 hr after infection), when administered at the dose of 100 mg/kg. In experiments carried out with Cebus monkeys, the drug was shown to be fully effective at 25 mg/kg, 7 days after infection. These data, associated with the good results obtained earlier at the post-postural phase of schistosomiasis, allow the inference that this promising compound may be important in the set of antischistosomal drugs, depending on further toxicological and clinical tests.
化合物Ro-15.5458/000属于9-吖啶酮腙类衍生物，已发现其对感染曼氏血吸虫的小鼠有效，以100毫克/千克的剂量给药时，几乎能杀死所有皮肤期血吸虫幼虫（感染后24小时）。在用卷尾猴进行的实验中，该药物在感染后7天以25毫克/千克的剂量给药时显示出完全有效。这些数据，再加上早期在血吸虫病晚期阶段取得的良好结果，可以推断，这种有前景的化合物在抗血吸虫药物组中可能很重要，这取决于进一步的毒理学和临床试验。
