Rud'ko I A, Balashova T S, Kubatiev A A, Ermolenko V M
Ter Arkh. 1995;67(8):7-9.
Lipid peroxidation as shown by malonic dialdehyde (MDA) levels and enzymic antioxidant defense systems were evaluated in red cells from patients with renal affections free of chronic renal failure (group 1), in conservative curable stage of chronic renal failure (group 2a), in terminal stage nondialysis patients (group 2b) and in healthy donors. MDA was higher in patients, in group 2b in particular. MDA levels correlated with concentrations of endogenic creatinine in the serum. Catalase and glutathione peroxidase were at control levels. SOD was not changed in group 1 but appeared reduced in other groups. Its activity was not related to serum creatinine. An inverse relationship existed between MDA content and SOD activity in red cells. It is believed that progression of chronic renal insufficiency leads to activation of lipid peroxidation and deterioration of antioxidant defense in red cells contributing to more active red cell destruction causing anemia in uremia.
通过丙二醛（MDA）水平评估脂质过氧化作用，并对无慢性肾衰竭的肾病患者（第1组）、处于慢性肾衰竭保守可治阶段的患者（第2a组）、终末期非透析患者（第2b组）以及健康供体的红细胞中的酶促抗氧化防御系统进行了评估。患者体内的MDA水平较高，尤其是第2b组。MDA水平与血清中内源性肌酐的浓度相关。过氧化氢酶和谷胱甘肽过氧化物酶处于对照水平。超氧化物歧化酶（SOD）在第1组中未发生变化，但在其他组中似乎有所降低。其活性与血清肌酐无关。红细胞中MDA含量与SOD活性呈负相关。据信，慢性肾功能不全的进展会导致脂质过氧化作用的激活以及红细胞中抗氧化防御功能的恶化，从而导致红细胞更活跃地破坏，引发尿毒症性贫血。
